Highlights
- •Lysozyme deposition starts saturating on the orthokeratology lens after one week.
- •Surface roughness increases after tear film component deposition for both lens materials.
- •Tear film component adsorption reduces transmission of visible light of both lens materials.
Abstract
Purpose
To understand the effects of long-term deposition of tear film components on the surface
and optical properties of orthokeratology (ortho-k) lenses, two different lenses, Brighten 22 and Optimum Extra, were tested here.
Methods
Ortho-k lenses were immersed in artificial tears and cleaned with a commercial care
solution repeatedly for up to 90 days. Both the daily and accumulated lysozyme deposition
amounts using an Enzyme-Linked ImmunoSorbent Assay were then analyzed. The base curve,
central thickness, power, and transmission of visible light, ultraviolet A, and ultraviolet
B were analyzed before and after repeated tear film component deposition procedures.
The surface roughness using atomic force microscopy was observed and an energy dispersive
spectrometer was used to analyze the composition of the deposits.
Results
The highest levels of lysozyme were adsorbed on both lens materials during the first
four days of the procedure and became saturated by day 6. For both lens materials,
contamination on the lenses was easily observed by day 30, and the degree of surface
roughness was higher. The transmission levels of different light spectrums were reduced
showing that the optical characteristics of both lenses were also affected.
Conclusions
The results provide in vitro evidence that lysozyme could not be completely removed from orthokeratology lenses.
Both surface and optical properties were affected by the deposition of tear film components.
However, only one commercial multipurpose care solution was used to clean the lens
in this study when the main ingredient was a surfactant, and the results might be
different when other care regimens with other key ingredients are used. In addition,
whether tear film component deposition might result in increased risks of infection
or corneal abrasion will require further investigation.
Keywords
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Article info
Publication history
Published online: May 05, 2023
Accepted:
April 28,
2023
Received in revised form:
March 8,
2023
Received:
August 31,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Published by Elsevier Ltd on behalf of British Contact Lens Association.
