Abstract
Objective
To describe the demographics and clinical profile of Secondary Lipid Keratopathy in
patients presenting to a multi-tier ophthalmology hospital network in India.
Methods
This cross-sectional hospital-based study included 3,082,727 new patients presenting
between August 2010 and December 2021. Patients with a clinical diagnosis of Secondary
Lipid Keratopathy in at least one eye were included as cases. The data were collected
using an electronic medical record system.
Results
Overall, 389 (0.01%) patients were diagnosed with Secondary Lipid Keratopathy. Majority
were males (53.5%) and had a unilateral affliction (82.8%). The most common age group
at presentation was during the sixth decade of life with 76 (19.5%) patients. The
overall prevalence was higher in patients from a lower socio-economic status (0.02%)
presenting from the rural geography (0.01%) and in individuals related to agriculture
work/ manual labor (0.02%). Of the 456 eyes, mild or no visual impairment (<20/70)
was noted in 194 (42.5%) eyes followed by moderate visual impairment (>20/70 to 20/200)
in 81 (17.8%) eyes. At presentation, the mean visual acuity was 0.96 ± 1.07 log MAR
units. The most associated corneal condition was non-HSV corneal scar (36.8%), followed
by spheroidal degeneration (19.7%) and HSV keratitis in (18.6%).
Conclusion
Secondary lipid keratopathy more commonly affected males presenting during the sixth
decade of life. Most (42.5%) of the eyes had mild or no visual impairment. Corneal
scar (non-HSV) was the most associated corneal condition in both unilateral and bilateral
cases. HSV keratitis was the commonest corneal condition in those between 20 and 40 years,
followed by those above 40 years.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Contact Lens and Anterior EyeAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cholesterol keratopathy.Am J Ophthalmol. 1969; 67: 372-375
- Ophthalmologisch-histologische Mittheilungen.Graefe’s Arch für Ophthalmol. 1876; 22: 185-203
- Lipid Keratopathy and Atheroma.Circulation. 1958; 18: 519-525
- Lipid keratopathy. An electron microscopic study.Arch Ophthalmol. 1970; 83: 678-691
- Primary lipid keratopathy: a morphological and biochemical assessment.Br J Ophthalmol. 1993; 77: 248-250
- Lipid keratopathy: a review of pathophysiology, differential diagnosis, and management.Ophthalmol Ther. 2020; 9: 833-852
- Photodynamic therapy with verteporfin for corneal neovascularization.Am J Ophthalmol. 2007; 144: 390-395
- Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin).Ocul Surf. 2012; 10: 67-83
- Fine needle diathermy occlusion of corneal vessels.Invest Ophthalmol Vis Sci. 2000; 41: 2148-2153
- Integrated model of primary and secondary eye care for underserved rural areas: the L V Prasad Eye Institute experience.Indian J Ophthalmol. 2012; 60: 396-400
- Big data and the eyeSmart electronic medical record system - An 8-year experience from a three-tier eye care network in India.Indian J Ophthalmol. 2020; 68: 427-432
World Health Organization. (2008). Change the Definition of Blindness [PDF file]. Retrieved from https://www.who.int/blindness/Change%20the%20Definition%20of%20Blindness.pdf.
- Corneal blindness in a southern Indian population: need for health promotion strategies.Br J Ophthalmol. 2003; 87: 133-141
- Herpes simplex epithelial and stromal keratitis: an epidemiologic update.Surv Ophthalmol. 2012; 57: 448-462
Article info
Publication history
Published online: March 15, 2023
Accepted:
March 3,
2023
Received in revised form:
February 25,
2023
Received:
December 7,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.