Abstract
Objective
To determine changes in various ocular parameters of adults wearing orthokeratology
(ortho-k) lenses and their levels of satisfaction and quality of life (QoL) after commencing
treatment.
Methods
Adults aged 18–38 years, with mild to moderate myopia and astigmatism < 1.50D, were
wearing ortho-k lenses for one year. Data collection, which included history taking, refraction,
axial length (AL), corneal topography, corneal biomechanics, and biomicroscopy examination,
was performed at baseline and every 6 months during the study period. The level of
satisfaction with the treatment and QoL was determined via questionnaires.
Results
Forty-four subjects completed the study. AL was shortened significantly at the 12-month
visit: AL −0.03 (-0.45 to 0.13) mm compared to baseline (p < 0.05). A significant number of subjects in both groups presented with overall and
central corneal staining, but the majority were mild (Grade 1). Central endothelial
cell density was reduced by 40/mm2 (loss rate 1.4 %) (p < 0.05). High scores were obtained in the satisfaction questionnaire, with no significant
differences between visits. At the 12-month visit, NEI-RQL-42 total score, dependence
on correction, activity limitation, appearance, and satisfaction with the treatment
all significantly increased compared to baseline values.
Conclusions
Results suggest that ortho-k can be an effective and safe myopia correction technique for adults with low to
moderate myopia, improving daytime vision without serious adverse events. Satisfaction
with ortho-k lens wear was high, particularly those who were dependent on vision correction
and found spectacles or contact lenses limiting specific activities or cosmetically
undesirable.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Contact Lens and Anterior EyeAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050.Ophthalmology. 2000; 2016: 1036-1042https://doi.org/10.1016/j.ophtha.2016.01.006
- The epidemics of myopia: Aetiology and prevention.Prog Retin Eye Res. 2018; 62: 134-149https://doi.org/10.1016/j.preteyeres.2017.09.004
- High Prevalence of Myopia and High Myopia in 5060 Chinese University Students in Shanghai.Invest Ophthalmol Vis Sci. 2012; 53: 7504https://doi.org/10.1167/iovs.11-8343
- Promoting the healthy development of modern orthokeratologhy in China.Chin J Ophthalmol. 2007; 43: 676-679https://doi.org/10.3760/j.issn:0412-4081.2007.08.002
- Overnight orthokeratology: preliminary results of the Lenses and Overnight Orthokeratology (LOOK) study.Optom Vis Sci. 2002; 79: 598-605https://doi.org/10.1097/00006324-200209000-00011
- Reduction of myopia from corneal refractive therapy.Optom Vis Sci. 2005; 82: 512-518https://doi.org/10.1097/01.opx.0000166772.68413.0e
- Orthokeratology review and update.Clin Exp Optom. 2006; 89: 124-143https://doi.org/10.1111/j.1444-0938.2006.00044.x
- Overnight corneal reshaping versus soft disposable contact lenses: vision-related quality-of-life differences from a randomized clinical trial.Optom Vis Sci. 2005; 82: 886-891https://doi.org/10.1097/01.opx.0000180818.40127.dc
- Near binocular visual function in young adult orthokeratology versus soft contact lens wearers.Cont Lens Anterior Eye. 2017; 40: 184-189https://doi.org/10.1016/j.clae.2017.01.003
- Changes in higher order wavefront aberrations after contact lens corneal refractive therapy and LASIK surgery.J Refract Surg. 2010; 26: 348-355https://doi.org/10.3928/1081597x-20100218-03
- The prevalence and pattern of contact lens use in a Singapore community.Clao J. 2000; 26: 21-25
- Reasons for Laser in Situ Keratomileusis in China: A Qualitative Study.Optom Vis Sci. 2019; 96: 206-212https://doi.org/10.1097/OPX.0000000000001352
- A Study on the Popularity and reasons for Napping in China.Renlei Gongxiao Xue. 2000; 6: 16-19https://doi.org/10.13837/j.issn.1006-8309.2000.02.005
- Nighttime sleep, Chinese afternoon nap, and mortality in the elderly.Sleep. 2007; : 1105-1110https://doi.org/10.1093/sleep/30.9.1105
- Ethnic differences in dry eye symptoms: effects of corneal staining and length of contact lens wear.Cont Lens Anterior Eye. 2013; 36: 281-288https://doi.org/10.1016/j.clae.2013.06.001
- The impact of contemporary contact lenses on contact lens discontinuation.Eye Contact Lens. 2013; 39: 93-99https://doi.org/10.1097/ICL.0b013e318271caf4
- A Review of Contact Lens Dropout.Clin Optom (Auckl). 2020; 25: 85-94https://doi.org/10.2147/OPTO.S198637
- Treating Uncomfortable Contact Lens Wear With Orthokeratology.Eye Contact Lens. 2020; 47: 74-80https://doi.org/10.1097/ICL.0000000000000690
- The Study of Progression of Adult Nearsightedness (SPAN): design and baseline characteristics.Optom Vis Sci. 2006; 83: 594-604https://doi.org/10.1097/01.opx.0000230274.42843.28
- The progression of myopia from its onset at age 8–12 to adulthood and the influence of heredity and external factors on myopic progression. A 23-year follow-up study.Acta Ophthalmol. 2014; 92: 730-739https://doi.org/10.1111/aos.12387
- Corneal reshaping and myopia progression.Br J Ophthalmol. 2009; 93: 1181-1185https://doi.org/10.1136/bjo.2008.151365
- Empirical versus trial set fitting systems for accelerated orthokeratology.Eye Contact Lens. 2005; 31 137https://doi.org/10.1097/01.icl.0000146170.27288.a3
- Clinical performance of an orthokeratology lens fitted with the aid of a computer software in Chinese children.Cont Lens Anterior Eye. 2012; 35: 180-184https://doi.org/10.1016/j.clae.2012.01.004
- Refractive and corneal responses of young myopic children to short-term orthokeratology treatment with different compression factors.Cont Lens Anterior Eye. 2020; 43: 65-72https://doi.org/10.1016/j.clae.2019.10.134
- Quantifying Regression with Orthokeratology.Contact Lens Spectrum, 2005
- The validity of the Jessen formula in overnight orthokeratology: a retrospective study.Ophthalmic Physiol Opt. 2008; 28: 265-268https://doi.org/10.1111/j.1475-1313.2008.00545.x
- Weekly Changes in Axial Length and Choroidal Thickness in Children During and Following Orthokeratology Treatment With Different Compression Factors.Transl Vis Sci Technol. 2019; 8: 9https://doi.org/10.1167/tvst.8.4.9
- Orthokeratology in adults and factors affecting success: Study design and preliminary results.Cont Lens Anterior Eye. 2020; 43: 595-601https://doi.org/10.1016/j.clae.2020.03.016
- Compression Factor and Visual Performance in Adults Treated With Orthokeratology. Eye Contact Lens. 2021; 47: 413-419https://doi.org/10.1097/ICL.0000000000000796
- Contact Lens Complications.Grading scales. third ed. Philadelphia, 2012: 1-31
- Reliability and validity of refractive error-specific quality-of-life instruments.Arch Ophthalmol. 2003; 121: 1289-1296https://doi.org/10.1001/archopht.121.9.1289
- The longitudinal orthokeratology research in children (LORIC) in Hong Kong: a pilot study on refractive changes and myopic control.Curr Eye Res. 2005; 30: 71-80https://doi.org/10.1080/02713680590907256
- High myopia-partial reduction ortho-k: a 2-year randomized study.Optom Vis Sci. 2013; 90: 530-539https://doi.org/10.1097/OPX.0b013e318293657d
- Influence of overnight orthokeratology on axial elongation in childhood myopia.Invest Ophthalmol Vis Sci. 2011; 52: 2170https://doi.org/10.1167/iovs.10-5485
- Toric orthokeratology for highly astigmatic children.Optom Vis Sci. 2012; 89: 849-855https://doi.org/10.1097/OPX.0b013e318257c20f
- Orthokeratology practice in children in a university clinic in Hong Kong.Clin Exp Optom. 2008; 91: 453-460https://doi.org/10.1111/j.1444-0938.2008.00259.x
- The effect of age on short-term orthokeratology.Optom Vis Sci. 2005; 82: 505-511https://doi.org/10.1097/01.opx.0000168583.17327.6d
- Analysis on sleeping time among Chinese population.Chin J Prev Chron Non-commun Dis. 2006; 14: 68-71https://doi.org/10.3969/j.issn.1004-6194.2006.02.002
- Myopia Control during Orthokeratology Lens Wear in Children Using a Novel Study Design.Ophthalmology. 2015; 122: 620-630https://doi.org/10.1016/j.ophtha.2014.09.028
- Protective Role of Orthokeratology in Reducing Risk of Rapid Axial Elongation: A Reanalysis of Data From the ROMIO and TO-SEE Studies.Invest Ophthalmol Vis Sci. 2017; 58: 1411https://doi.org/10.1167/iovs.16-20594
- Effects of Orthokeratology on Choroidal Thickness and Axial Length.Optom Vis Sci. 2016; 93: 1064-1071https://doi.org/10.1097/opx.0000000000000894
- Choroidal thickness and axial length changes in myopic children treated with orthokeratology.Cont Lens Anterior Eye. 2017; 40: 417-423https://doi.org/10.1016/j.clae.2017.09.010
- Retardation of myopia in Orthokeratology (ROMIO) study: a 2-year randomized clinical trial.Invest Ophthalmol Vis Sci. 2012; 53: 7077https://doi.org/10.1167/iovs.12-10565
- Combined atropine with orthokeratology for myopia control: study design and preliminary results.Curr Eye Res. 2019; 44: 671-678https://doi.org/10.1080/02713683.2019.1568501
- Orthokeratology vs. spectacles: adverse events and discontinuations.Optom Vis Sci. 2012; 89: 1133-1139https://doi.org/10.1097/OPX.0b013e318263c5af
- Myopia control using toric orthokeratology (TO-SEE study).Invest Ophthalmol Vis Sci. 2013; 54: 6510https://doi.org/10.1167/iovs.13-12527
- Comparison of reverse-geometry lens designs for overnight orthokeratology.Optom Vis Sci. 2003; 80: 796-804https://doi.org/10.1097/00006324-200312000-00009
- The Safety of Orthokeratology—A Systematic Review.Eye Contact Lens. 2016; 42: 35-42https://doi.org/10.1097/ICL.0000000000000219
- The Children’s Overnight Orthokeratology Investigation (COOKI) pilot study.Optom Vis Sci. 2004; 81: 407-413https://doi.org/10.1097/01.opx.0000135093.77007.18
- Does a two-year period of orthokeratology lead to changes in the endothelial morphology of children?.Cont Lens Anterior Eye. 2018; 41: 214-218https://doi.org/10.1016/j.clae.2017.10.006
- Long-term changes in corneal morphology induced by overnight orthokeratology.Curr Eye Res. 2011; 36: 895-904https://doi.org/10.3109/02713683.2011.593723
- The control effect of orthokeratology on axial length elongation in Chinese children with myopia.BMC Ophthalmol. 2014; 14: 141https://doi.org/10.1186/1471-2415-14-141
- Precision of cell density estimates and endothelial cell loss with age.Arch Ophthalmol. 1985; 103: 1478-1481https://doi.org/10.1001/archopht.1985.01050100054017
- A comparative study of human corneal keratocyte and endothelial cell density during aging.Cornea. 1997; 16: 333-338https://doi.org/10.1097/00003226-199705000-00014
- Subjective satisfaction in long-term orthokeratology patients.Eye Contact Lens. 2013; 39: 388-393https://doi.org/10.1097/ICL.0b013e3182a27777
- Established soft contact lens wearers’ awareness of and initial experiences with orthokeratology.Ophthalmic Physiol Opt. 2021; 41: 673-682https://doi.org/10.1111/opo.12828
- The effect of overnight contact lens corneal reshaping on refractive error-specific quality of life.Optom Vis Sci. 2006; 83: 354-359https://doi.org/10.1097/01.opx.0000221401.33776.54
- Quality of life of myopic subjects with different methods of visual correction using the NEI RQL-42 questionnaire.Eye Contact Lens. 2012; 38: 116-121https://doi.org/10.1097/ICL.0b013e3182480e97
- Vision-Specific Quality of Life: Laser-Assisted in situ Keratomileusis Versus Overnight Contact Lens Wear.Eye Contact Lens. 2018; 45: 34-39https://doi.org/10.1097/icl.0000000000000538
Article info
Publication history
Published online: March 09, 2023
Accepted:
February 20,
2023
Received in revised form:
February 19,
2023
Received:
July 29,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.