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Repeatability and correlation of corneal biomechanical measurements obtained by Corvis ST in orthokeratology patients

  • Weicong Lu
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Wenzhi Ding
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Rongyuan Ji
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Yuyin Tian
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Chenpei Zhao
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Honglei Li
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Mengjun Jiao
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Zhen Guo
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
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  • Lin Leng
    Correspondence
    Corresponding author at: 5 Yanerdao Road, Qingdao, China.
    Affiliations
    Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China

    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China

    School of Ophthalmology, Shandong First Medical University, Shandong, China
    Search for articles by this author
Published:December 09, 2022DOI:https://doi.org/10.1016/j.clae.2022.101793

      Abstract

      Purpose

      To evaluate the repeatability of the corneal biomechanical measurements obtained by Corvis ST in post-orthokeratology patients and analyze the correlation between the biomechanical and ocular parameters.

      Methods

      Fifty-one eyes of 51 myopic subjects were included in this study. The biomechanical parameters were assessed using Corvis ST. Repeatability was assessed using one-way ANOVA based on within-subject standard deviation (Sw), repeatability coefficient (RC), intraclass correlation coefficient (ICC) and correlation of variation (CoV). The correlation was evaluated using Pearson correlation analysis.

      Results

      All parameters measured by Corvis ST, except length of flattened cornea at the first and second applanations (A1L and A2L), showed a good intraobserver repeatability after a 3-month follow-up period. The ICC values for A1L and A2L were 0.444 and 0.654, whereas the other parameters were higher than 0.8. Similar trends were obtained for CoV, wherein the CoV values for A1L and A2L were greater than 13 %. The corneal biomechanical parameters were correlated with age, refraction, axial length (AL), steep and flat keratometry before and after orthokeratology, and central corneal thickness (CCT). Following orthokeratology treatment, post-keratometry demonstrated a higher correlation with stiffness parameter at first applanation (SP-A1), velocity of corneal apex at the first applanation (A1V), and radius than pre-keratometry, which showed a weak correlation with SP-A1.

      Conclusion

      Corneal biomechanical parameters assessed using Corvis ST demonstrated a good repeatability, except A1L and A2L. The corneal biomechanical parameters were correlated with age, refraction, AL and pre- and post-keratometry. Thus, Corvis ST is a suitable device for investigating biomechanical parameter.

      Keywords

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