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The effect of corneal power distribution on axial elongation in children using three different orthokeratology lens designs

  • Zhe Zhang
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
  • Jiaqi Zhou
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
  • Li Zeng
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
  • Feng Xue
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
  • Xingtao Zhou
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
  • Zhi Chen
    Correspondence
    Corresponding author.
    Affiliations
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    NHC Key Laboratory of Myopia (Fudan University), Shanghai, China

    Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
    Search for articles by this author
Published:August 22, 2022DOI:https://doi.org/10.1016/j.clae.2022.101749

      Abstract

      Purpose

      To investigate the correlation between spatial corneal power distribution and one-year axial length (AL) elongation using three ortho-k lens designs by a unified mathematical method.

      Methods

      A total of 137 subjects were included: 42 with Euclid lenses, 28 with DRL lenses, and 67 with CRT lenses. AL elongation, Xmax, Ymax and power exponent were compared among the three groups. One-year relative corneal refractive power change (RCRPC) was calculated by a polynomial function and a monomial function. Factors including age, baseline spherical equivalent refractive error (SER), Xmax, Ymax and power exponent was tested against one-year AL growth in a stepwise multiple linear regression model.

      Results

      The power exponent (F = 7.29, P = 0.0012) and Xmax (F = 62.88, P < 0.0001) of the DRL group was significantly smaller than that of the other two lens groups. Ymax was not significantly different among three lens groups (F = 1.18, P = 0.31). The one-year AL elongation of the DRL group (0.09 ± 0.14 mm) was significantly slower than that of the Euclid group (0.26 ± 0.14 mm, P = 0.002) and CRT group (0.32 ± 0.18 mm, P < 0.0001). AL elongation was significantly correlated with Xmax (standardized β = 0.196, P = 0.003), power exponent (standardized β = 0.644, P < 0.001), and age (standardized β = -0.263, P < 0.001), with R2 being 0.608.

      Conclusion

      A smaller and more aspheric treatment zone may be beneficial for reducing axial elongation in children undergoing ortho-k treatment, regardless of their baseline myopic refractive error.

      Keywords

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