Advertisement

Outcomes of scleral lenses for dry eye disease in chronic ocular graft-versus-host disease

      Ocular graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation, seen in approximately 40% of patients [
      • Jacobs R.
      • Tran U.
      • Chen H.
      • Kassim A.
      • Engelhardt B.G.
      • Greer J.P.
      • et al.
      Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria.
      ]. Dry eye symptoms in ocular GVHD can be debilitating [
      • Sun Y.C.
      • Chai X.
      • Inamoto Y.
      • Pidala J.
      • Martin P.J.
      • Flowers M.E.
      • et al.
      Impact of ocular chronic graft-versus-host disease on quality of life.
      ,
      • Saboo U.S.
      • Amparo F.
      • Abud T.B.
      • Schaumberg D.A.
      • Dana R.
      Vision-related quality of life in patients with ocular graft-versus-host disease.
      ]. Despite initial measures such as frequent preservative-free lubrication, autologous serum drops, punctal occlusion, and topical steroids, symptoms can be refractory [
      • Magro L.
      • Gauthier J.
      • Richet M.
      • Robin M.
      • Nguyen S.
      • Suarez F.
      • et al.
      Scleral lenses for severe chronic GvHD-related keratoconjunctivitis sicca: a retrospective study by the SFGM-TC.
      ].

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Contact Lens and Anterior Eye
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References:

        • Jacobs R.
        • Tran U.
        • Chen H.
        • Kassim A.
        • Engelhardt B.G.
        • Greer J.P.
        • et al.
        Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria.
        Bone Marrow Transplant. 2012; 47: 1470-1473https://doi.org/10.1038/bmt.2012.5
        • Sun Y.C.
        • Chai X.
        • Inamoto Y.
        • Pidala J.
        • Martin P.J.
        • Flowers M.E.
        • et al.
        Impact of ocular chronic graft-versus-host disease on quality of life.
        Biol Blood Marrow Transplant. 2015; 21: 1687-1691https://doi.org/10.1016/j.bbmt.2015.05.020
        • Saboo U.S.
        • Amparo F.
        • Abud T.B.
        • Schaumberg D.A.
        • Dana R.
        Vision-related quality of life in patients with ocular graft-versus-host disease.
        Ophthalmology. 2015; 122: 1669-1674https://doi.org/10.1016/j.ophtha.2015.04.011
        • Magro L.
        • Gauthier J.
        • Richet M.
        • Robin M.
        • Nguyen S.
        • Suarez F.
        • et al.
        Scleral lenses for severe chronic GvHD-related keratoconjunctivitis sicca: a retrospective study by the SFGM-TC.
        Bone Marrow Transplant. 2017; 52: 878-882https://doi.org/10.1038/bmt.2017.9
        • Bavinger J.C.
        • DeLoss K.
        • Mian S.I.
        Scleral lens use in dry eye syndrome.
        Curr Opin Ophthalmol. 2015; 26: 319-324https://doi.org/10.1097/ICU.0000000000000171
        • Jacobs D.S.
        • Rosenthal P.
        Boston scleral lens prosthetic device for treatment of severe dry eye in chronic graft-versus-host disease.
        Cornea. 2007; 26: 1195-1199https://doi.org/10.1097/ICO.0b013e318155743d
        • Theophanous C.
        • Irvine J.A.
        • Parker P.
        • Chiu G.B.
        Use of Prosthetic Replacement of the Ocular Surface Ecosystem scleral lenses in patients with ocular chronic graft-versus-host disease.
        Biol Blood Marrow Transplant. 2015; 21: 2180-2184https://doi.org/10.1016/j.bbmt.2015.07.027
        • Stoyanova E.I.
        • Otten H.M.
        • Wisse R.
        • Rothova A.
        • Riemens A.
        Bandage and scleral contact lenses for ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
        Acta Ophthalmol. 2015; 93: e604
        • Schornack M.M.
        • Baratz K.H.
        • Patel S.V.
        • Maguire L.J.
        Jupiter scleral lenses in the management of chronic graft versus host disease.
        Eye Contact Lens. 2008; 34: 302-305https://doi.org/10.1097/ICL.0b013e318188e205
        • Takahide K.
        • Parker P.M.
        • Wu M.
        • Hwang W.Y.K.
        • Carpenter P.A.
        • Moravec C.
        • et al.
        Use of fluid-ventilated, gas-permeable scleral lens for management of severe keratoconjunctivitis sicca secondary to chronic graft-versus-host disease.
        Biol Blood Marrow Transplant. 2007; 13: 1016-1021https://doi.org/10.1016/j.bbmt.2007.05.006
        • Agranat J.
        • Kitos N.R.
        • Jacobs D.S.
        Prosthetic replacement of the ocular surface ecosystem: impact at 5 years.
        Br J Ophthalmol. 2016; 100: 1171-1175https://doi.org/10.1136/bjophthalmol-2015-307483
        • Jagasia M.H.
        • Greinix H.T.
        • Arora M.
        • Williams K.M.
        • Wolff D.
        • Cowen E.W.
        • et al.
        National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report.
        Biology of Blood and Marrow Transplantation. 2015; 21: 389-401.e1
        • Lee S.K.
        • Cook E.F.
        • Soiffer R.
        • Antin J.H.
        Development and validation of a scale to measure symptoms of chronic graft-versus-host disease.
        Biol Blood Marrow Transplant. 2002; 8: 444-452https://doi.org/10.1053/bbmt.2002.v8.pm12234170
        • Stason W.B.
        • Razavi M.
        • Jacobs D.S.
        • Shepard D.S.
        • Suaya J.A.
        • Johns L.
        • et al.
        Clinical benefits of the Boston ocular surface prosthesis.
        Am J Ophthalmol. 2010; 149: 54-61https://doi.org/10.1016/j.ajo.2009.07.037
        • Moon J.
        • Lee S.
        • Hyon J.Y.
        • Kim M.K.
        • Oh J.Y.
        • Choi H.J.
        Large diameter scleral lens benefits for Asians with intractable ocular surface disease: a prospective, single-arm clinical trial.
        Sci Rep. 2021; 11: 2288https://doi.org/10.1038/s41598-021-82010-z