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Effect of overnight orthokeratology lenses on tear film stability in children

Published:April 04, 2022DOI:https://doi.org/10.1016/j.clae.2022.101592

      Abstract

      Purpose

      To assess the tear film surface quality after orthokeratology using an automated Medmont E300 corneal topographer.

      Methods

      Children who wore orthokeratology lenses for more than one year were selected in this retrospective study. Tear film disruption (TFD) and central tear film disruption (cTFD) were measured with Medmont E300 corneal topographer at initial and each follow-up visit after fitting with orthokeratology lenses, providing a nominal value from 0 (perfect) to 1 (poor). Tear film surface quality before and after ortho-k treatment was compared.

      Results

      145 children using orthokeratology lenses were observed. TFD and cTFD significantly increased at 1-day follow up (TFD, t = -17.3, P < 0.001; cTFD, t = -10.4, P < 0.001). This change remained consistent through to 12-months visit (TFD, F = 51.1, P < 0.001; cTFD, F = 28.0, P < 0.001). A sub-group of n = 11 children were discontinued for 1-month before being refit with OrthoK lenses of a different design. Similarly, there was a significant increase in TFD compared to pre-orthoK scans (0.172 ± 0.161), but this returned to baseline levels after ceasing lens wear (0.084 ± 0.059). A sub-group of monocular OrthoK wearers (n = 23) found that TFD and cTFD values increased in eyes with monocular lens-wearing but remained stable in the lateral eyes.

      Conclusions

      Objective measurements of tear-film quality are reduced in children after fitting with orthokeratology lenses, but return to baseline after 1-month of lens cessation. It is of importance to ensure tear film surface quality is continuously monitored throughout use of orthoK lenses.

      Keywords

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      References

        • Vencent S.J.
        • Cho P.
        • Chan K.Y.
        • Fadel D.
        • Ghorbani-Mojarrad N.
        • Gonzalez-Meijome J.M.
        • et al.
        CLEAR-Orthokeratology.
        Cont Lens Anterior Eye. 2021; 44: 240-269
        • Xie P.
        • Guo X.
        Chinese experiences on orthokeratology.
        Eye Contact Lens. 2016; 42: 43-47
        • VanderVeen D.K.
        • Kraker R.T.
        • Pineles S.L.
        • Hutchinson A.K.
        • Wilson L.B.
        • Galvin J.A.
        • et al.
        Use of orthokeratology for the prevention of myopic progression in children: a report by the American Academy of Ophthalmology.
        Ophthalmology. 2019; 126: 623-636
        • Fonn D.
        • Peterson R.
        • Woods C.
        Corneal Staining as a Response to Contact Lens Wear.
        Eye Contact Lens. 2010; 5: 318-321
        • Mann A.
        • Tighe B.
        Contact lens interactions with the tear film.
        Exp Eye Res. 2013; 117: 88-98
        • Li J.
        • Dong P.
        • Liu H.
        Effect of Overnight Wear Orthokeratology Lenses on Corneal Shape and Tears.
        Eye Contact Lens. 2018; 44: 304-307
        • Nieto-Bona A.
        • Nombela-Palomo M.
        • Felipe-Marquez G.
        • Teus M.A.
        Tear film osmolarity in response to long-term orthokeratology treatment.
        Eye Contact Lens. 2018; 44: 85-90
        • Na K.S.
        • Yoo Y.S.
        • Hwang H.S.
        • Mok J.W.
        • Kim H.S.
        • Joo C.K.
        The influence of overnight orthokeratology on ocular surface and Meibomian glands in children and adolescents.
        Eye Contact Lens. 2016; 42: 68-73
        • Hosaka E.
        • Kawamorita T.
        • Ogasawara Y.
        • Nakayama N.
        • Uozato H.
        • Shimizu K.
        • et al.
        Interferometry in the evaluation of precorneal tear film thickness in dry eye.
        Am J Ophthalmol. 2011; 151: 18-23.e1
        • Koh S.
        • Mada N.
        Wavefront sensing and the dynamics of tear film.
        Cornea. 2007; 26: S41-S45
        • Qunnoughene Y.
        • Benhatchi N.
        • Agboke J.
        • Beauchet A.
        • Baudouin C.
        The Video Tearscope: a new method for evaluating lacrimal film in vivo.
        J Fr Ophthalmol. 2006; 29: 476-484
        • Alonso-Caneiro D.
        • Iskander D.R.
        • Collins M.J.
        Assessment of tear film surface quality using dynamic-area high-speed videokeratoscopy.
        IEEE Trans Biomed Eng. 2009; 56: 1473-1481
        • Downie L.E.
        Automated Tear Film Surface Quality Breakup Time as a Novel Clinical Marker for Tear Hyperosmolarity in Dry Eye Disease.
        Invest Ophthalmol Vis Sci. 2015; 56: 7260-7268
        • Llorens-Quintana C.
        • Iskander D.R.
        Assessment of tear film using videokeratoscopy based on fractal dimension.
        Optom Vis Sci. 2018; 95: 32-42
        • Alonso-Caneiro D.
        • Iskander D.R.
        • Collins M.J.
        Tear film surface quality with soft contact lenses using dynamic-area high-speed videokeratoscopy.
        Eye Contact Lens. 2009; 35: 227-231
        • Tyagi G.
        • Alonso-Caneiro D.
        • Collins M.
        • Read S.
        Tear film surface quality with rigid and soft contact lenses.
        Eye Contact Lens. 2012; 38: 171-178
        • Alonso-Caneiro D.
        • Turuwhenua J.
        • Iskander D.R.
        • Collins M.J.
        Diagnosing dry eye with dynamic-area high-speed videokeratoscopy.
        J Biomed Opt. 2011; 16: 076012
        • Guo Y.
        • Duan J.L.
        • Liu L.J.
        • Sun Y.
        • Tang P.
        • Lv Y.Y.
        • et al.
        High myopia in Greater Beijing school children in 2016.
        PLoS One. 2017; 12: e0187396
        • Wu L.J.
        • You Q.S.
        • Duan J.L.
        • Luo Y.X.
        • Liu L.J.
        • Li X.
        • et al.
        Prevalence and associated factors of myopia in high-school students in Beijing.
        PLoS One. 2015; 10: e0120764
        • Liu Y.M.
        • Xie P.
        The safety of orthokeratology-A systematic review.
        Eye Contact Lens. 2016; 42: 35-42
        • Cheng H.-C.
        • Liang J.-B.
        • Lin W.-P.
        • Wu R.
        Effectiveness and safety of overnight orthokeratology with Boston XO2 high-permeability lens material: A 24 week follow-up study.
        Cont Lens Anterior Eye. 2016; 39: 67-71
        • Van Meter W.S.
        • Musch D.C.
        • Jacobs D.S.
        • Kaufman S.C.
        • Reinhart W.J.
        • Udell I.J.
        • et al.
        Safety of overnight orthokeratology for myopia: a report by the American Academy of Ophthalmology.
        Ophthalmology. 2008; 115: 2301-2313
        • Mika R.
        • Morgan B.
        • Cron M.
        • Lotoczky J.
        • Pole J.
        Safety and efficacy of overnight orthokeratology in myopic children.
        Optometry. 2007; 78: 225-231
        • Lin M.C.
        • Graham A.D.
        • Fusaro R.E.
        • Plose K.A.
        Impact of rigid gas-permeable contact lens extended wear on corneal epithelial barrier function.
        Invest Ophthalmol Vis Sci. 2002; 43: 1019-1024
        • Hiraoka T.
        • Sekine Y.
        • Okamoto F.
        • Mihashi T.
        • Oshika T.
        Safety and efficacy following 10-years of overnight orthokeratology for myopia control.
        Ophthalmic Physiol Opt. 2018; 38: 281-289
        • Bron A.J.
        • Argüeso P.
        • Irkec M.
        • Bright F.V.
        Clinical staining of the ocular surface: mechanisms and interpretations.
        Prog Retinal Eye Res. 2015; 44: 36-61
        • Morgan P.B.
        • Maldonado-Codina C.
        Corneal staining: Do we really understand what we are seeing?.
        Contact lens Anterior Eye. 2009; 32: 48-54
        • Guillon J.-P.
        • Guillon M.
        • Malgouyres S.
        Corneal desiccation staining with hydrogel lenses: tear film and contact lens factors.
        Ophthalmic Physiol Opt. 1990; 10: 343-350
        • Nichols J.J.
        • Sinnott L.T.
        Tear film, contact, and patients factors associated with corneal staining.
        Invest Ophthalmol Vis Sci. 2011; 52: 1127-1137
        • Panaser A.
        • Tighe B.J.
        Evidence of lipid degradation during overnight contact lens wear: gas chromatography mass spectrometry as the diagnostic tool.
        Invest Ophthalmol Vis Sci. 2014; 55: 1797-1804