Keratoconus is the most common sight threatening non-inflammatory corneal ectasia
affecting younger patients. In most cases the condition is bilateral and asymmetrical.
At presentation, which is usually initiated due to diminishing best corrected VA,
and an otherwise unexplained progression of astigmatic refractive error, primary care
optometrists attribute a presumed diagnosis, based largely on the quality of the retinoscopy
reflex. As the disease progresses alterations to the corneal profile, resulting in
central stromal thinning, and a characteristic inferior corneal conical protrusion,
appear. Two excellent review papers appearing almost 10 years apart in CLAE, provide
the reader with a comprehensive overview of the subject [
1
,
Romero-Jim ́enez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye 2010;33:157–66. https://doi.org/10.1016/j. clae.2010.04.006.
2
]. Between 1998 and 2022 a total of 174 papers which include the word Keratoconus in
the title, or as a keyword, have been published in CLAE. Twenty-one papers referring
to different aspects of, or associations with, keratoconus, in the title have been
published in the last 4 CLAE volumes (2018–2022). Varied and interesting topics covered
include keratoconus; corneal endothelial morphology; scleral topography; ocular aberrations;
diagnostic procedures; keratoplasty; scleral rigid gas permeable (RGP) contact lenses
(CLs); corneal crosslinking; intraocular pressure.Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: An updated review. Cont Lens Anterior Eye 2022. Jan 3;101559. https://doi.org/10.1016/j.clae.2021.101559.
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References
Romero-Jim ́enez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye 2010;33:157–66. https://doi.org/10.1016/j. clae.2010.04.006.
Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: An updated review. Cont Lens Anterior Eye 2022. Jan 3;101559. https://doi.org/10.1016/j.clae.2021.101559.
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- Changes in collagen orientation and distribution in keratoconus corneas.Invest Ophthalmol Visual Sci. 2005; 46: 1948https://doi.org/10.1167/iovs.04-1253
- Molecular and histopathological changes associated with keratoconus.Biomed Res Int. 2017; 2017: 1-16https://doi.org/10.1155/2017/7803029
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- Repeatability of anterior segment measurements by optical coherence tomography combined with Placido disk corneal topography in eyes with keratoconus.Sci Rep. 2020; 10: 1-6
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- Treatment of keratoconus by collagen cross linking.Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2003; 100: 44-49
- Comparison of standard and accelerated corneal cross-linking for the treatment of keratoconus: a meta-analysis.Acta Ophthalmol. 2019; 97: e22-e35
- Accelerated pulsed high-fluence corneal cross-linking for progressive keratoconus.Am J Ophthalmol. 2021; 221: 9-16
- Corneal collagen cross-linking epithelium-on vs. epithelium-off: a systematic review and meta-analysis.Eye Vis. 2021; 8: 1-15
- Effectiveness of intrastromal corneal ring implantation in the treatment of adult patients with keratoconus: a systematic review.J Refract Surg. 2019; 35: 191-200
- Combined wavefront-guided transepithelial photorefractive keratectomy and corneal crosslinking for visual rehabilitation in moderate keratoconus.J Cataract Refract Surg. 2018; 44: 571-580
- Effect of corneal cross-linking versus standard care on keratoconus progression in young patients: the KERALINK randomized controlled trial.Ophthalmology. 2021; 128: 1516-1526
- Nationwide reduction in the number of corneal transplantations for keratoconus following the implementation of cross-linking.Acta Ophthalmol. 2016; 94: 675-678
- Outcomes of femtosecond laser-assisted mushroom-configuration keratoplasty in advanced keratoconus.Eye. 2016; 30: 553-561
Article info
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Published online: February 21, 2022
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© 2022 Published by Elsevier Ltd on behalf of British Contact Lens Association.
