Abstract
Aims
Considering individual variability in regards to the effects of orthokeratology (ortho-k) on myopia progression and controversies regarding the precise underlying mechanism,
the aim of this study was to investigate several ocular measurements associated with
axial length (AL) growth in children wearing ortho-k lenses.
Methods
In this retrospective chart review, medical records of 53 Chinese children who wore
ortho-k lenses over the course of 12 months were reviewed. Baseline variables included
age at initiation of ortho-k wear, refractive error (spherical equivalent, SE), central corneal thickness (CCT),
and flat and steep keratometry of corneal principal meridians. The change of anterior
chamber depth (ACD) and the change of crystalline lens thickness (CLT) between baseline
and the 12-month follow-up were also analyzed. The contributions of all analyzed variables
to AL change were assessed using univariate and multivariate regression analyses.
Results
Initially, the results of paired t-test showed that CLT and AL were significantly increased after 12 months of ortho-k wear compared with that at baseline (P = 0.001 and < 0.001). The ACD did not change
significantly after 12 months compared with that at baseline (P = 0.491). Subsequently,
univariate analyses showed that a reduced rate of AL elongation was found in children
who were older age at initiation of ortho-k wear (P = 0.028), had greater SE (higher degree of myopia) at baseline (p = 0.006),
had thicker CCT at baseline (P = 0.04), and had greater increase of CLT (P = 0.001)
in 12 months. At last, only greater SE (higher degree of myopia) and greater increase
of CLT were associated with smaller increases of AL in multivariable analyses, (P = 0.003
and 0.001).
Conclusions
Both CLT and AL were significantly increased in children with overnight ortho-k wear after 12 months of follow-up. Greater baseline SE and greater increase of
CLT were associated with less increase in AL during ortho-k wear in children with myopia.
Keywords
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Article info
Publication history
Published online: November 10, 2021
Accepted:
November 1,
2021
Received in revised form:
October 23,
2021
Received:
February 6,
2021
Identification
Copyright
© 2021 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
