Abstract
Smoking is a risk factor for the development of microbial keratitis and corneal infiltrates
in contact lens (CL) wearers. It is still unknown if this risk is directly associated
with the presence of nicotine in the eye and if adherence of nicotine on the CL can
enhance these effects. A better understanding of the interaction between nicotine
and CL materials could offer insights to explain this risk associated with smoking.
The aim of this work was to compare the affinity of nicotine to different soft CL
materials. CLs from FDA groups I, II, IV, and V were incubated in a 2-mM nicotine
solution for 24 h and then in a 0.9% saline solution for the next 24 h. The amount
of absorbed and released nicotine per CL was deduced as a function of time (t) by
ultraviolet (UV) spectrophotometry and normalised to the mass of the hydrated CL.
The data were described by the equation y = b –a t−1, where a and b are constants, and b represents the mass reached at the plateau after ~ 10 min
of exposure. Groups IV and V displayed the highest (0.80 ± 0.09 µg) and lowest (0.27 ± 0.08 µg)
nicotine absorption per mg of hydrated CL, respectively. The CL affinity for nicotine
could be ascribed to the interaction between the positive charge of nicotine pyrrolidine
nitrogen and the negative charges of the CLs, especially for the ionic IV group.
Keywords
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Article info
Publication history
Published online: July 19, 2021
Accepted:
July 7,
2021
Received in revised form:
July 2,
2021
Received:
March 25,
2021
Identification
Copyright
© 2021 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
