Abstract
Purpose
To investigate the ocular subclinical inflammatory response in two soft contact lens
materials when used in combination with two different care systems (‘solutions’).
Methods
Fifteen established soft contact lens wearers wore each of two lenses: Acuvue® 2 (CH) and Acuvue® Oasys® (SiH) or no lenses in random sequence for one week. Two care systems were used: a
peroxide system: Oxysept 1 Step® (P) for the right lens and Opti-Free® Replenish® (MPS) for the left lens. After one week of lens/no lens wear, in vivo confocal microscopy (IVCM) of corneal and conjunctival regions was carried out. Density
of presumed dendritic cells (DC) and ‘white spots’ (WS) were quantified. Impression
cytology of the bulbar and upper eyelid margin conjunctivae was carried out and samples
were analysed for CD45+, CD3+ and CD11c+ cells.
Results
The SiH + MPS combination showed a greater inflammatory response compared to SiH + P
in seven out of 12 parameters investigated (p < 0.05). The remaining five were not
statistically different between the two solutions. The converse was found for the
CH lens, with four of the 12 parameters showing a greater response with the P solution
compared to the MPS (p < 0.05).
Conclusion
This study suggests that the SiH lens investigated demonstrated an upregulated response
when used with a MPS compared to a P solution whereas the converse is true for the
CH lens which showed a reduced response when used with a MPS compared to a P solution.
This finding aids in the understanding of the biological underpinnings of manifest
corneal inflammatory events during contact lens wear.
Keywords
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Article info
Publication history
Published online: July 16, 2021
Accepted:
July 7,
2021
Received in revised form:
July 3,
2021
Received:
March 4,
2021
Identification
Copyright
© 2021 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
