Abstract
Purpose
To analyse the one-month change in subfoveal choroidal thickness (SFChT) of myopic
children treated with 0.01 % atropine, orthokeratology (OK), or their combination.
Methods
This is a prospective, randomized controlled trial. One hundred fifty-four children
aged between 8 and 12 years with a spherical equivalent (SE) of -1.00 to -6.00 diopters
were enrolled. Subjects were randomly assigned to receive 0.01 % atropine and orthokeratology
(ACO, n = 39), 0.01 % atropine and single vision glasses (atropine, n = 42), orthokeratology
and placebo (OK, n = 36), or placebo and single vision glasses (control, n = 37).
SFChT was assessed using optical coherence tomography (OCT). Ocular parameters, including
axial length (AL), were measured using a Lenstar LS 900.
Results
SFChT significantly increased in the ACO (14.12 ± 12.88 μm, p < 0.001), OK (9.43 ± 9.14 μm,
p < 0.001) and atropine (5.49 ± 9.38 μm, p < 0.001) groups, while it significantly
decreased in the control group (-4.81 ± 9.93 μm, p = 0.006). The one-month change
in SFChT was significantly different between the control and treatment groups (p < 0.001).
The results of pairwise comparisons among the treatment groups showed that the magnitude
of the SFChT change was larger in the ACO group than in the atropine group (p = 0.002).
The changes in the ACO and OK groups were not significantly different (p = 0.326).
Conclusion
The combination of OK and atropine induced a greater increase in SFChT than monotherapy
with atropine, which might indicate a better treatment effect for childhood myopia
control.
Keywords
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Article info
Publication history
Published online: June 30, 2020
Accepted:
June 18,
2020
Received in revised form:
June 17,
2020
Received:
January 16,
2020
Identification
Copyright
© 2020 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
