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Review article| Volume 44, ISSUE 3, 101331, June 2021

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Diagnosis and remediation of blink inefficiency

      Abstract

      To examine the role of incomplete blinking in contributing to blink inefficiency, symptoms of dry eye and ocular surface disease. To review methods for diagnosing blink inefficiency (including both reduced overall blink rate and increased incomplete blink rate) and the role of remediation for efficient complete blinking as an essential part of the lacrimal functional unit in maintaining tear homeostasis. Diagnosis and remediation of blink inefficiency appear to have been somewhat misunderstood in the management of dry eye disease. To the extent that a high incomplete blink rate ranks in significance with low blink frequency in contributing to blink inefficiency, measures and remediation of only total blink rate are of reduced usefulness in the diagnosis and treatment of blink inefficiency-related ocular surface exposure, dry eye symptoms and ocular surface disease. In addition, a patient’s blink performance during a biomicroscopy or any other clinical assessment of blink efficiency, is unlikely to be characteristic of or relevant to the blink inefficiency that develops and causes symptoms during their various day-to-day activities. There appears to be a strong case for prescribing blink efficiency exercises in the management of many cases of dry eye symptoms and ocular surface disease. Remediation of spontaneous blink inefficiency may require that a motor memory of voluntary complete, rapid, relaxed and natural looking blink formation is established and maintained as the basis for efficient spontaneous blinking. Voluntary forceful blinking may undermine the motor memory of efficient blinking and risk the depletion of any reserves of lipid.

      Keywords

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      References

        • Craig J.P.
        • Nichols K.K.
        • Akpek E.K.
        • Caffery B.
        • Dua H.S.
        • Joo C.-K.
        • et al.
        TFOS DEWS II definition and classification report.
        Ocul Surf. 2017; 15: 276-283
        • Stern M.E.
        • Gao J.
        • Siemasko K.F.
        • Beuerman R.W.
        • Pflugfelder S.C.
        The role of the lacrimal functional unit in the pathophysiology of dry eye.
        Exp Eye Res. 2004; 78: 409-416
        • Stern M.E.
        • Schaumburg C.S.
        • Pflugfelder S.C.
        Dry eye as a mucosal autoimmune disease.
        Inter Rev Immunol. 2013; 32: 19-41
        • Geerling G.
        • Baudouin C.
        • Aragona P.
        • Rolando M.
        • Boboridis K.G.
        • Benitez-del-Castillo J.M.
        • et al.
        Emerging strategies for the diagnosis and treatment of meibomian gland dysfunction: proceedings of the OCEAN group meeting.
        Ocul Surf. 2017; 15: 179-192
        • Blehm C.
        • Vishnu S.
        • Khattak A.
        • Mitra S.
        • Yee R.W.
        Computer vision syndrome: a review.
        Surv Ophthalmol. 2005; 50: 253-262
        • Chu C.A.
        • Rosenfield M.
        • Portello J.K.
        Blink patterns: reading from a computer screen versus hard copy.
        Optom Vis Sci. 2014; 91: 297-302
        • McMonnies C.W.
        Incomplete blinking: exposure keratopathy, lid wiper epitheliopathy, dry eye, refractive surgery, and dry contact lenses.
        Cont Lens Anterior Eye. 2007; 30: 37-51
        • Portello J.K.
        • Rosenfield M.
        • Chu C.A.
        Blink rate, incomplete blinks and computer vision syndrome.
        Optom Vis Sci. 2013; 90: 482-487
        • Korb D.R.
        • Blackie C.A.
        Evidence suggesting that the keratinized portions of the upper and lower lid margins do not make complete contact during deliberate blinking.
        Cornea. 2013; 32: 491-495
        • Pult H.
        • Riede-Pult B.H.
        • Murphy P.J.
        A new perspective on spontaneous blinks.
        Ophthalmology. 2013; 120: 1086-1091
        • Pult H.
        • Korb D.R.
        • Murphy P.J.
        • Riede-Pult B.H.
        • Blackie C.
        A new model of central lid apposition and tear film mixing in spontaneous blinking.
        Cont Lens Anterior Eye. 2015; 38: 173-180
        • McMonnies C.W.
        The clinical and experimental significance of blinking behavior.
        J Optom. 2020; https://doi.org/10.1016/j.optom.2019.09.002
        • Rodriguez J.D.
        • Lane K.J.
        • Ousler III G.W.
        • Angjeli E.
        • Smith L.M.
        • et al.
        Blink: characteristics, controls, and relation to dry eyes.
        Curr Eye Res. 2018; 43: 52-66
        • Woods J.
        • Hutchings N.
        • Srinivasan S.
        • Jones L.
        Geographic distribution of corneal staining in symptomatic dry eye.
        Ocul Surf. 2020; 18: 258-266
        • Golebiowski B.
        • Long J.
        • Harrison K.
        • Lee A.
        • Chidi-Egboka N.
        • Asper L.
        Smartphone use and effects on tear film, blinking and binocular vision.
        Curr Eye Res. 2020; (10/1080/02713683.2019.1663542)
        • Wang MTM Tien L.
        • Han A.
        • Lee J.M.
        • Kim D.
        • Markouli M.
        • et al.
        Impact of blinking on ocular surface and tear film parameters.
        Ocul Surf. 2018; 16: 424-429
        • Nakamura S.
        • Shibuya M.
        • Nakashima H.
        • Hisamura R.
        • Masuda N.
        • Imagawa T.
        • et al.
        Involvement of oxidative stress on corneal epithelial alterations in blink-suppressed dry eye.
        Invest Ophthalmol Vis Sci. 2007; 48: 1552-1558
        • Ousler G.W.
        • Wilcox K.W.
        • Schindelar M.
        • Welch D.
        • Abelson M.B.
        The ocular protection index.
        Cornea. 2008; 27: 509-513
        • Carney L.G.
        • Hill R.M.
        The nature of normal blinking patterns.
        Acta Ophthalmol (Copenh). 1982; 60: 427-433
        • Abelson M.B.
        • Holly F.J.
        A tentative mechanism for inferior punctate keratopathy.
        Am J Ophthal. 1977; 83: 866-869
        • Collins M.J.
        • Iskander D.R.
        • Saunders A.
        • Hook S.
        • Anthony E.
        • Gillon R.
        Blinking patterns and corneal staining.
        Eye Cont Lens. 2006; 32: 287-293
        • Drew G.C.
        Variations in reflex blink-rate during visual-motor tasks.
        Quart J Exp Psychol. 1951; 3: 73-88
        • Himebaugh N.L.
        • Begley C.G.
        • Bradley A.
        • Wilkinson J.A.
        Blinking and tear break-up during four visual tasks.
        Optom Vis Sci. 2009; 86: E106-E114
        • McMonnies C.W.
        Blink efficiency: a neglected area of ocular surface disease management.
        Invest Ophthalmol Vis Sci. 2011; 52: 4484
        • McMonnies C.W.
        Incomplete blinking and dysfunctional tear syndromes.
        Br J Ophthalmol. 2010; 94: 1552
        • Jonkees B.J.
        • Colzato L.S.
        Spontaneous eye blink rate as predictor of dopamine-related cognitive function: a review.
        Neurosci Biobehav Rev. 2016; 71: 58-72
        • Korb D.R.
        • Herman J.P.
        Corneal staining subsequent to sequential fluorescein instillations.
        J Am Optom Assoc. 1979; 50: 316-317
        • Chhadva P.
        • Lee T.
        • Sarantopoulos C.D.
        • Hackam A.S.
        • McClellan A.L.
        • Felix E.R.
        • et al.
        Human tear serotonin levels correlate with symptoms and signs of dry eye.
        Ophthalmology. 2015; 122: 1675-1680
        • Miura D.L.
        • Hazarbassanov R.M.
        • Karim C.
        • Yamasato M.
        • Bandeira e Silva F.
        • et al.
        Effect of a light emitting timer device on the blink rate of non-dry eye individuals and dry eye patients.
        Br J Ophthalmol. 2013; 97: 965-967
        • Ang C.K.
        • Mohidin N.
        • Chung K.M.
        Effects of wink glass on blink rate, NIBUT and ocular surface symptoms during visual display unit use.
        Curr Eye Res. 2014; 39: 879-884
        • Cardona G.
        • Gomez M.
        • Quevedo L.
        • Gipets J.
        Effect of transient blur and screen luminance changes on eyeblink rate.
        Cont Lens Anterior Eye. 2014; 37: 363-367
        • Rosenfield M.
        • Portello J.K.
        Computer vision syndrome and blink rate.
        Curr Eye Res. 2016; 41: 577-578
        • Nosch D.S.
        • Foppa C.
        • Toth M.
        • Joos R.E.
        Blink animation software to improve blinking and dry eye symptoms.
        Optom Vis Sci. 2015; 92: e310-e315
        • Miyake-Kashima M.
        • Dogru M.
        • Nojima T.
        • Murase M.
        • Matsumoto Y.
        • Tsubota K.
        The effect of antireflection film on blink rate and asthenopic symptoms during visual display terminal work.
        Cornea. 2005; 24: 567-570
        • Park J.
        • Baek S.
        Dry eye syndrome in thyroid eye disease patients: the role of increased incomplete blinking and meibomian gland loss.
        Acta Ophthalmol (Copenh). 2019; 97: e800-e806
        • Li Y.
        • Li S.
        • Zhou J.
        • Liu C.
        • Xu M.
        Relationship between lipid layer thickness, incomplete blinking rate and tear film instability in patients with different myopia degrees after small-incision lenticule extraction.
        PLoS ONE. 2020; 15: e0230119https://doi.org/10.1371/journal.pone.0230119
        • Doughty M.J.
        Consideration of three types of spontaneous eyeblink activity in normal humans: during reading and video display terminal use, in primary gaze, and while in conversation.
        Optom Vis Sci. 2001; 78: 712-725
        • Linton R.G.
        • Curnow D.H.
        • Riley W.J.
        The Meibomian glands. An investigation into the secretion and some aspects of the physiology.
        Br J Ophthalmol. 1961; 45: 718-723
        • Ruskell G.L.
        Anatomy and physiology of the cornea and related structures.
        in: Phillips A.J. Stone J. Contact lenses. 3rd ed. Butterworths, London1989: 44
        • Chou Y.-B.
        • Fan N.-W.
        • Lin P.-Y.
        Value of lipid layer thickness and blinP.-Y. Patterns in approaching patients with dry eye symptoms.
        Can J Ophthalmol. 2019; 54: 735-738
        • Korb D.R.
        • Baron D.F.
        • Herman J.P.
        • Finnemore V.M.
        • Exford J.M.
        • et al.
        Tear film lipid layer thickness as a function of blinking.
        Cornea. 1994; 13: 354-359
        • Tomlinson A.
        • Bron A.J.
        • Korb D.R.
        • Amano S.
        • Paugh J.R.
        • Pearce E.I.
        • et al.
        The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee.
        Invest Ophthalmol Vis Sci. 2011; 52: 2006-2049
        • Stefan K.
        • Cohen L.G.
        • Duque J.
        • Mazzochio R.
        • Celnik P.
        • Sawaki L.
        • et al.
        Formation of motor memory by action observation.
        J Neurosci. 2005; 25: 9339-9346
        • Kaelin-Lang A.
        • Sawaki L.
        • Cohen L.G.
        Role of voluntary drive in encoding an elementary motor memory.
        J Neurophysiol. 2005; 93: 1099-1103
        • Lotze M.
        • Braun C.
        • Birbaumer N.
        • Anders S.
        • Cohen L.G.
        Motor learning elicited by voluntary drive.
        Brain. 2003; 126: 866-872
        • Shadmehr R.
        • Brashers-Krug T.
        Functional stages in the formation of human long-term motor memory.
        J Neurosci. 1997; 17: 409-419
        • Yamazaki T.
        • Nagao S.
        • Lennon W.
        • Tanaka S.
        Modeling memory consolidation during postraining periods in cerebellovestibular learning.
        PNAS. 2015; 112: 3541-3546
        • Brashers-Krug T.
        • Shadmehr R.
        • Bizzi E.
        Consolidation in human motor memory.
        Nature. 1996; 382: 252-254
        • McMaster N.
        Behaviour modification with hypnotic visualization; the mental side of golf. A case history.
        Austr J Clin Hypnother Hypnosis. 1993; 14: 17-22
        • Chu Y.
        • Sell T.C.
        • Lephart S.M.
        The relationship between biomechanical variables and driving performance during the golf swing.
        J Sport Sci. 2010; 28: 1251-1259
        • Floel A.
        • Breitenstein C.
        • Hummel F.
        • Celnik P.
        • Gingert C.
        • Sawaki L.
        • et al.
        Dopaminergic influences on formation of a motor memory.
        Ann Neurol. 2005; 58: 121-130
        • Holly F.J.
        • Lemp M.A.
        Tear physiology and dry eyes.
        Surv Ophthalmol. 1977; 22: 69-87
        • Lemp M.A.
        Advances in understanding and managing dry eye disease.
        Am J Ophthalmol. 2008; 146: 350-356
        • Anshel J.R.
        Visual ergonomics in the workplace.
        Am Assoc Occup Health Nurs. 2007; 55: 414-420
        • McMonnies C.W.
        How blink anomalies can contribute to post-LASIK neurotrophic epitheliopathy.
        Optom Vis Sci. 2015; 92: e241-e247
        • Elston J.S.
        • Casgranje F.
        • Lees A.J.
        The relationship between eye-winking tics, frequent eye-blinking and blepharospasm.
        J Neurol Psychiatr. 1989; 52: 477-480
        • Munoz E.
        • Cervera A.
        • Valls-Sole J.
        Neurophysiological study of facial chorea in patients with Huntington’s disease.
        Clin Neurophysiol. 2003; 114: 1246-1252
        • Hallak J.A.
        • Jassim S.
        • Khanolkar V.
        • Jain S.
        Symptom burden of patients with dry eye disease: a four-domain analysis.
        PLoS ONE. 2013; 8: 1-8
        • Coles-Brennan C.
        • Sulley A.
        • Young G.
        Management of digital eye strain.
        Clin Exp Optom. 2019; 102: 18-29
        • Serin D.
        • Karshoglu S.
        • Kiyan A.
        • Alagoz G.
        A simple approach to the repeatability of the Schirmer test without anesthesia.
        Cornea. 2007; 26: 903-906
        • Farrand K.F.
        • Fridman M.
        • Stillman I.O.
        • Schaumberg D.A.
        Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older.
        Am J Ophthalmol. 2017; 182: 90-98
        • Collins M.
        • Heron H.
        • Larsen R.
        • Lindner R.
        Blinking patterns in soft contact lens wearers can be altered with training.
        Am J Optom Physiol Opt. 1987; 6: 100-103
        • Young G.
        • Veys J.
        • Pritchard N.
        • Coleman S.
        A multi-centre study of lapsed contact lens wearers.
        Ophthalmic Physiol Opt. 2002; 22: 516-527