Abstract
Purpose
To evaluate the changes in corneal epithelial thickness and corneal anterior and posterior
curvatures during the day, and the effect of wearing daily disposable soft contact
lenses.
Methods
Thirty-two healthy volunteers were enrolled in a randomized crossover study. At the
baseline visit, corneal and epithelial thickness maps (OCT; Optovue, Inc., Fremont,
CA, USA) and keratometric measurements (Pentacam, Oculus, GmbH, Germany) were performed
in the morning and in the afternoon (8 hours after). Then, each subject was fitted
with the following brands of daily disposable contact lenses in random order: Dailies
Total 1 (Delefilcon A), Dailies Aqua Comfort (Nelfilcon A), TruEye (Narafilcon A)
and Biotrue Oneday (Nesofilcon A) on different days. All fitted lenses had a power
of −3.00 diopters (D). Measurements were repeated before putting the contact lens
on and after an-eight-hour contact lens wear.
Results
With no lens wear, the anterior topographic indices showed significant steepening
[Kflat: p < 0.0001; Ksteep: p < 0.0001 and maximum keratometry value (Kmax): p = 0.04]
and the corneal thickness significantly decreased in the central and temporal portion
of the cornea in the afternoon. There were no significant changes in the posterior
topographical indices and corneal epithelial thickness. With contact lens wear, no
significant change occurred in the corneal and epithelial thickness, and the anterior
and posterior curvatures during the day (all p values >0.05). There was no statistically
significant difference in the epithelial thickness among the groups wearing different
contact lens types (p > 0.05).
Conclusions
Anterior corneal topographic indices steepen depending on the natural diurnal variations.
Daily wear of soft contact lenses appears to mask this steepening. The corneal epithelial
thickness is not affected by daily disposable soft contact lenses.
Keywords
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Article info
Publication history
Published online: December 10, 2019
Accepted:
November 30,
2019
Received in revised form:
November 29,
2019
Received:
July 15,
2019
Identification
Copyright
© 2019 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
