Abstract
Purpose
To compare the effect of single-drop administration of two different ophthalmic solutions
on tear meniscus and tear osmolarity in patients with mild to moderate dry eye disease.
Methods
This prospective study comprised of 122 patients with mild to moderate dry eye disease.
These patients received a single dose of either unpreserved trehalose 3%, hyaluronic
acid 0.15%, carbomer 0.25% (TH HA, Thealoz Duo Gel) (Group 1) or hyaluronic acid 0.3% (HA) (Group 2) gel-based lubricants.
Tear meniscus (height and depth) were measured using anterior segment optic coherence
tomography (AS−OCT) at baseline and 10, 60, 120, and 240 min. after instillation.
Tear osmolarity, Schirmer I test, tear break-up time (TBUT), gel properties, and patient
comfort were evaluated 240 min. after instillation.
Results
Tear meniscus height (TMH) and tear meniscus depth (TMD) showed a significant increase
with both lubricants compared to the baseline (p < 0.001). This effect remained significant
for up to 60 min. and 120 min. for the TH HA and HA 0.3% solutions, respectively (p < 0.05, for both). Mean comfort duration
was 115.1 ± 20.1 min. in Group 1 and 148.3 ± 49.0 min in Group 2 (p < 0.001). Tear
osmolarity, Schirmer I test, and TBUT were similar between the baseline and 240 min.
for each group.
Conclusions
The results of this study demonstrate that 0.3% HA remains on the ocular surface for
longer than TH-HA. The longer ocular residency time also seems to correlate with a
longer patient comfort duration.
Keywords
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Article info
Publication history
Published online: October 12, 2019
Accepted:
October 1,
2019
Received in revised form:
October 1,
2019
Received:
June 30,
2019
Identification
Copyright
© 2019 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
