Highlights
- •Randomised double-masked paired-eye trial in symptomatic dry eye subjects (n = 30).
- •Lipid and non-lipid drop instilled before simulated adverse environment exposure.
- •Tear film parameters measured at baseline, post-instillation and post-exposure.
- •Both drops prevented tear film stability from declining below baseline levels.
- •Lipid drop superior prophylactically at maintaining lipid layer quality.
Abstract
Purpose
To compare the prophylactic efficacy of single application of lipid and non-lipid
containing tear supplements, prior to exposure of symptomatic dry eye subjects to
a simulated adverse environment.
Methods
Thirty subjects with mild-to-moderate dry eye symptoms participated in the prospective,
randomised, double-masked, paired-eye trial. A lipomimetic drop (Systane® Balance) was applied to one eye (randomised), and a non-lipid containing drop (Systane® Ultra) applied simultaneously to the contralateral eye. Subjects were subsequently
exposed to a validated simulated adverse environment model created by a standing fan
directed towards the eye, at a distance of 1 m, for 2.5 min. Low contrast glare acuity, lipid layer grade (LLG), non-invasive tear break-up
time (NIBUT), temperature variation factor (TVF), and tear meniscus height (TMH) were
evaluated at baseline, following eye drop instillation and following simulated adverse
environment exposure.
Results
Both therapies resulted in increased NIBUT (both p < 0.001), and prevented its decline below baseline with simulated adverse environment
exposure (both p > 0.05). However, only the lipomimetic drop increased LLG (p < 0.001) and precluded its fall below baseline post-adverse environment exposure (p = 0.15). Furthermore, post-instillation and post-exposure LLGs and NIBUT were significantly
higher in the lipomimetic group (all p < 0.05). No significant changes were observed in glare acuity, TVF and TMH (all p > 0.05). More subjects (67%) reported greater ocular comfort in the eye receiving the
lipomimetic.
Conclusions
Single application of both lipid and non-lipid containing eye drops conferred protective
effects against exposure to adverse environmental conditions in subjects with mild-to-moderate
dry eye, although the lipomimetic demonstrated superior prophylactic efficacy.
Keywords
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Article info
Publication history
Published online: September 21, 2017
Accepted:
September 8,
2017
Received in revised form:
August 21,
2017
Received:
July 16,
2017
Identification
Copyright
© 2017 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
