Research Article| Volume 33, ISSUE 4, P189-195, August 2010

Clinical performance of different care systems with silicone hydrogel contact lenses

Published:March 04, 2010DOI:



      To assess the clinical and subjective performance of a one-step hydrogen peroxide (H2O2) lens care system compared to a multi-purpose disinfecting system (MPDS) when used with silicone hydrogel (SiH) lenses.


      This was an eight-week, contralateral (lens type) clinical trial with a randomized, cross-over (care system) design. The H2O2 system was Clear Care ((AO Sept Plus) CIBA VISION) and the MPDS was OPTI-FREE RepleniSH (Alcon) and the SiH materials were lotrafilcon B (Air Optix; CIBA VISION) and senofilcon A (Acuvue OASYS, Johnson & Johnson Vision Care). Investigators and subjects were masked to lens care and lens type, respectively. Clinical variables and ocular health assessments were conducted at a baseline, two-week and four-week visit for each cross-over phase. Comfort, dryness and vision were rated on 0–100 scales. Wearing times and comfortable wearing times were also recorded.


      Twenty-six subjects were enrolled: nine male, 17 female, mean age (±standard deviation) 31 ± 12 years (range 17–59 years) and 24 subjects completed the study. Clinical variables showed no difference between solutions (all p > 0.05), however one subject exhibited solution-induced corneal staining with both lens materials and the MPDS. There was no difference between solutions in subjective overall ratings of comfort, dryness or vision (p > 0.05). The H2O2 resulted in longer reported comfortable wearing times than the MPDS (10.93 ± 1.71 vs 9.84 ± 1.47 h; repeated measures ANOVA, p < 0.01).


      While both lens care systems performed well with the SiH lenses used, the H2O2 resulted in a longer reported comfortable wearing time then the MPDS.


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        • Maldonado-Codina C.
        • Morgan P.B.
        • Schnider C.M.
        • Efron N.
        Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses.
        Optom Vis Sci. 2004; 81: 911-921
        • Dumbleton K.
        • Keir N.
        • Moezzi A.
        • Feng Y.
        • Jones L.
        • Fonn D.
        Objective and subjective responses in patients refitted to daily-wear silicone hydrogel contact lenses.
        Optom Vis Sci. 2006; 83: 758-768
        • Stapleton F.
        • Stretton S.
        • Papas E.
        • Skotnitsky C.
        • Sweeney D.F.
        Silicone hydrogel contact lenses and the ocular surface.
        Ocul Surf. 2006; 4: 24-43
        • Efron N.
        • Morgan P.B.
        Trends in the use of silicone hydrogel contact lenses for daily wear.
        Cont Lens Anterior Eye. 2008;
        • Brennan N.A.
        • Coles M.L.
        • Comstock T.L.
        • Levy B.
        A 1-year prospective clinical trial of balafilcon a (PureVision) silicone–hydrogel contact lenses used on a 30-day continuous wear schedule.
        Ophthalmology. 2002; 109: 1172-1177
        • Chalmers R.
        • Long B.
        • Dillehay S.
        • Begley C.
        Improving contact-lens related dryness symptoms with silicone hydrogel lenses.
        Optom Vis Sci. 2008; 85: 778-784
        • Riley C.
        • Young G.
        • Chalmers R.
        Prevalence of ocular surface symptoms, signs, and uncomfortable hours of wear in contact lens wearers: the effect of refitting with daily-wear silicone hydrogel lenses (senofilcon a).
        Eye Contact Lens. 2006; 32: 281-286
        • Schafer J.
        • Mitchell G.L.
        • Chalmers R.L.
        • Long B.
        • Dillehay S.
        • Barr J.
        • et al.
        The stability of dryness symptoms after refitting with silicone hydrogel contact lenses over 3 years.
        Eye Contact Lens. 2007; 33: 247-252
        • Chalmers R.L.
        • Dillehay S.
        • Long B.
        • Barr J.T.
        • Bergenske P.
        • Donshik P.
        • et al.
        Impact of previous extended and daily wear schedules on signs and symptoms with high Dk lotrafilcon A lenses.
        Optom Vis Sci. 2005; 82: 549-554
        • Fonn D.
        • Dumbleton K.
        Dryness and discomfort with silicone hydrogel contact lenses.
        Eye Contact Lens. 2003; 29 ([discussion S115-108, S192-104]): S101-S104
        • Cheung S.W.
        • Cho P.
        • Chan B.
        • Choy C.
        • Ng V.
        A comparative study of biweekly disposable contact lenses: silicone hydrogel versus hydrogel.
        Clin Exp Optom. 2007; 90: 124-131
        • Dumbleton K.A.
        • Woods C.A.
        • Jones L.W.
        • Fonn D.
        Comfort and adaptation to silicone hydrogel lenses for daily wear.
        Eye Contact Lens. 2008; 34: 215-223
        • Garofalo R.J.
        • Dassanayake N.
        • Carey C.
        • Stein J.
        • Stone R.
        • David R.
        Corneal staining and subjective symptoms with multipurpose solutions as a function of time.
        Eye Contact Lens. 2005; 31: 166-174
        • Jones L.
        • MacDougall N.
        • Sorbara L.G.
        Asymptomatic corneal staining associated with the use of balafilcon silicone–hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen.
        Optom Vis Sci. 2002; 79: 753-761
        • Carnt N.
        • Jalbert I.
        • Stretton S.
        • Naduvilath T.
        • Papas E.
        Solution toxicity in soft contact lens daily wear is associated with corneal inflammation.
        Optom Vis Sci. 2007; 84: 309-315
        • Andrasko G.
        • Ryen K.
        Corneal staining and comfort observed with traditional and silicone hydrogel lenses and multipurpose solution combinations.
        Optometry. 2008; 79: 444-454
        • Alfonso E.C.
        • Miller D.
        • Cantu-Dibildox J.
        • O’Brien T.P.
        • Schein O.D.
        Fungal keratitis associated with non-therapeutic soft contact lenses.
        Am J Ophthalmol. 2006; 142: 154-155
        • Joslin C.E.
        • Tu E.Y.
        • Shoff M.E.
        • et al.
        The association of contact lens solution use and Acanthamoeba keratitis.
        Am J Ophthalmol. 2007; 144: 169-180
        • Papas E.B.
        • Carnt N.
        • Willcox M.D.
        • Holden B.A.
        Complications associated with care product use during silicone daily wear of hydrogel contact lens.
        Eye Contact Lens. 2007; 33 ([discussion 399–400]): 392-393
        • Woods C.A.
        • Jones D.A.
        • Jones L.W.
        • Morgan P.B.
        A seven year survey of the contact lens prescribing habits of Canadian optometrists.
        Optom Vis Sci. 2007; 84: 505-510
        • Efron N.
        • Morgan P.B.
        Soft contact lens care regimens in the UK.
        Cont Lens Anterior Eye. 2008; 31: 283-284
        • Amos C.
        A clinical comparison of two soft lens care systems used with silicone hydrogel contact lenses.
        Optician. 2004; 227: 16-20
        • Bruce A.S.
        • Mainstone J.C.
        • Golding T.R.
        Analysis of tear film breakup on Etafilcon A hydrogel lenses.
        Biomaterials. 2001; 22: 3249-3256
        • Fonn D.
        • MacDonald K.E.
        • Richter D.
        • Pritchard N.
        The ocular response to extended wear of a high Dk silicone hydrogel contact lens.
        Clin Exp Optom. 2002; 85: 176-182
        • du Toit R.
        • Simpson T.L.
        • Fonn D.
        • Chalmers R.L.
        Recovery from hyperemia after overnight wear of low and high transmissibility hydrogel lenses.
        Curr Eye Res. 2001; 22: 68-73
        • Keay L.
        • Sweeney D.F.
        • Jalbert I.
        • Skotnitsky C.
        • Holden B.A.
        Microcyst response to high Dk/t silicone hydrogel contact lenses.
        Optom Vis Sci. 2000; 77: 582-585
        • Dalton K.
        • Subbaraman L.N.
        • Rogers R.
        • Jones L.
        Physical properties of soft contact lens solutions.
        Optom Vis Sci. 2008; 85: 122-128
        • Morgan P.B.
        • Maldonado-Codina C.
        • Chatterjee N.
        • Moody K.J.
        Elicitation of subjective responses via sms (text) messaging in contact lens clinical trials.
        Optom Vis Sci. 2007; ([E-abstract 075143])
        • Plowright A.
        • Morgan P.B.
        • Maldonado-Codina C.
        • Moody K.J.
        An investigation of ocular comfort in contact lens wearers, spectacle wearers and non-wearers.
        Optom Vis Sci. 2008; ([E-abstract 85050])