Objective clinical performance of ‘comfort-enhanced’ daily disposable soft contact lenses

Published:February 10, 2010DOI:



      To examine the objective clinical performance of ‘comfort-enhanced’ daily disposable contact lenses over a 16-h day.


      Four contact lenses (Hilafilcon B, Etafilcon A Plus, Nelfilcon A and Nelfilcon A Plus) were evaluated in an investigator masked, open label trial at the end of a week's bilateral wear. Pre-lens non-invasive tear break-up time (PL-NITBUT), tear prism height, bulbar hyperaemia and ocular surface temperature (OST) were measured with the lens in situ at 8, 12 and 16 h of wear.


      There was no difference between how many hours the lenses types were worn each day (F = 0.90, p = 0.44). The PL-NITBUT decreased with the duration of daily lens wear (F = 32.0, p < 0.001) and was more stable with Nelfilcon A Plus (F = 6.00, p = 0.002) than with the other lenses evaluated. Bulbar blood vessels increased in coverage (F = 11.5, p < 0.001) but not overall redness (F = 0.0, p = 0.99) with the duration of daily lens wear, but there was no difference between the lenses (p > 0.05). The tear prism height decreased with the duration of daily wear (F = 27.0, p < 0.001) and differed between lenses (F = 2.9, p = 0.04). The OST decreased with the duration of lens wear (F = 119.7, p < 0.001) and was reduced by daily disposable lens wear (F = 7.88, p < 0.001), but did not differ between lenses (F = 0.88, p = 0.45).


      Objective measures of tear film indicated a difference between the lenses evaluated for PL-NITBUT and tear prism height, but not for wearing time or bulbar conjunctival hyperaemia. Therefore clinical benefits of daily disposable ‘comfort enhancing’ contact lenses can be measured, but challenges remain in producing contact lenses that do not compromise anterior eye physiology over the whole day.


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        • Pritchard N.
        • Fonn D.
        • Brazeau D.
        Discontinuation of contact lens wear: a survey.
        Int Contact Lens Clin. 1999; 26: 157-162
        • Maruyama K.
        • Yokoi N.
        • Takehisa Y.
        • Kinoshita S.
        Effect of environmental conditions on tear dynamics in soft contact lens wearers.
        Invest Ophthalmol Vis Sci. 2004; 45: 2563-2568
        • Riley C.
        • Young G.
        • Chalmers R.
        Prevalence of ocular surface symptoms, signs, and uncomfortable hours of wear in contact lens wearers: the effect of refitting with daily-wear silicone hydrogel lenses (Senofilcon A).
        Eye Contact Lens. 2006; 32: 281-286
        • Begley C.G.
        • Chalmers R.L.
        • Mitchell G.L.
        • Nichols K.K.
        • Caffery B.
        • Simpson T.
        • et al.
        Characterization of ocular surface symptoms from optometric practices in North America.
        Cornea. 2001; 20: 610-618
        • Long B.
        • McNally J.
        The clinical performance of a silicone hydrogel lens for daily wear in an Asian population.
        Eye Contact Lens. 2006; 32: 65-71
        • Wolffsohn J.S.
        • Peterson R.C.
        • Nick J.
        • Winterton L.
        • Lally J.
        Clinical performance of daily disposable soft contact lenses using sustained release technology.
        Contact Lens Ant Eye. 2006; 29: 127-134
        • Riley K.C.
        • Chalmers R.L.
        • Pence N.
        The impact of lens choice in the relief of contact lens related symptoms and ocular surface findings.
        Contact Lens Ant Eye. 2005; 28: 13-19
        • Gulsen D.
        • Chauhan A.
        Ophthalmic drug delivery through contact lenses.
        Invest Ophthalmol Vis Sci. 2004; 45: 2342-2347
        • Mahomed A.
        • Tighe B.
        Contact lenses & comfort enhancers: in vivo and in vitro release of soluble PVA.
        Ophthalmic Res. 2004; 36: 34
        • Doughty M.J.
        Re-wetting, comfort, lubricant and moisturising solutions for the contact lens wearer.
        Contact Lens Ant Eye. 1999; 22: 116-126
        • Armstrong R.A.
        • Eperjesi F.
        • Gilmartin B.
        The application of analysis of variance (ANOVA) to different experimental designs in Optometry.
        Ophthalmic Physiol Opt. 2002; 22: 248-256
        • Wolffsohn J.S.
        • Purslow C.
        Clinical monitoring of ocular physiology using digital image analysis.
        Contact Lens Ant Eye. 2003; 26: 27-35
        • Purslow C.
        • Wolffsohn J.S.
        • Santodomingo-Rubido J.
        The effect of contact lens wear on dynamic ocular surface temperature.
        Contact Lens Ant Eye. 2005; 28: 29-36
        • Purslow C.
        • Wolffsohn J.S.
        Ocular surface temperature. A review.
        Eye Contact Lens. 2005; 31: 117-123
        • Guillon M.
        • Styles E.
        • Guillon J.P.
        • Maissa C.
        Preocular tear film characteristics of nonwearers and soft contact lens wearers.
        Optom Vis Sci. 1997; 74: 273-279
        • Glasson M.J.
        • Stapleton F.
        • Keay L.
        • Sweeney D.
        • Willcox M.D.P.
        Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers.
        Invest Ophthalmol Vis Sci. 2003; 44: 5116-5124
        • Johnson M.E.
        • Murphy J.P.
        The agreement and repeatability of tear meniscus height measurement methods.
        Optom Vis Sci. 2005; 82: 1030-1037
        • Bitton E.
        • Keech A.
        • Simpson T.
        • Jones L.
        Variability of the analysis of the tear meniscus height by optical coherence tomography.
        Optom Vis Sci. 2007; 84: 903-908
        • Fujishima H.
        • Yagi Y.
        • Shimazaki J.
        • Tsubota K.
        Effects of artificial tear temperature on corneal sensation and subjective comfort.
        Cornea. 1997; 16: 630-634