Contact Lens & Anterior Eye
Volume 33, Issue 4 , Pages 167-170 , August 2010

Evaluation of the microstructure of cornea by in vivo confocal microscopy in contact lens wearing and non-contact lens wearing keratoconus patients

  • Baris Yeniad

      Affiliations

    • Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology, Turkey
    • Corresponding Author InformationCorresponding author at: Istanbul Universitesi, Istanbul Tıp Fakültesi, Göz Hastaliklari A.D., Capa-Sehremini, 34093 Istanbul, Turkey. Tel.: +90 2124142000; fax: +90 2124142024.
    • ,
  • Senay Yilmaz

      Affiliations

    • Private practice
    • ,
  • Lale Kozer Bilgin

      Affiliations

    • Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology, Turkey

References 

  1. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297–319
  2. Cristina KM, Brown DJ. The cascade hypothesis of keratoconus. Contact Lens Anterior Eye. 2003;26:139–146
  3. Wilson SE, Mohan RR, Mohan RR, Ambrósio R, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma and inflammatory cells. Prog Retin Eye Res. 2001;20:625–637
  4. Hollingsworth JG, Bonshek RE, Efron N. Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy. Cornea. 2005;24:397–405
  5. Lawless M, Coster DJ, Phillips AJ, Loane M. Keratoconus: diagnosis and management. Aust NZ J Ophthalmol. 1989;17:33–60
  6. Sawaguchi S, Yue BY, Sugar J, Gilboy JE. Lysosomal enzyme abnormalities in keratoconus. Arch Ophthalmol. 1989;107:1507–1510
  7. Zhou L, Sawaguchi S, Twining SS, Sugar J, Feder RS, Yue BY. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci. 1998;39:1117–1124
  8. Efron N, Hollingsworth JG. New perspectives on keratoconus as revealed by corneal confocal microscopy. Clin Exp Optom. 2008;91:34–55
  9. Weed KH, MacEwen CJ, Cox A, McGhee CN. Quantative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy. Eye. 2007;21:614–623
  10. Ladage PM, Yamamoto K, Ren DH, Li L, Jester JV, Petroll WM, et al. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase and bacterial binding to exfoliated epithelial cells. Ophthalmology. 2001;108:1279–1288
  11. Erie JC, Patel SV, McLaren JW, Nau CB, Hodge DO, Bourne WM. Keratocyte density in keratoconus. A confocal microscopy study. Am J Ophthalmol. 2002;134:689–695
  12. Edmonds CR, Wung SF, Husz MJ, Pemberton B. Corneal endothelial cell count in keratoconus patients after contact lens wear. Eye Contact Lens. 2004;30:54–58
  13. Hollingsworth JG, Efron N, Tullo AB. In vivo confocal microscopy in keratoconus. Ophthalmic Physiol Opt. 2005;25:254–260
  14. Sherwin T, Brookes NH. Morphological changes in keratoconus: pathology or pathogenesis. Clin Exp Ophthalmol. 2004;32:211–217
  15. Kaldawy RM, Wagner J, Ching S, Seigel GM. Evidence of apoptotic cell death in keratoconus. Cornea. 2002;21:206–209
  16. Mocan MC, Yilmaz PT, Irkec M, Orhan M. In vivo confocal microscopy for the evaluation of corneal microstructure in keratoconus. Curr Eye Res. 2008;33:933–939
  17. Kallinikos P, Efron N. On the etiology of keratocyte loss during contact lens wear. Invest Ophthalmol Vis Sci. 2004;45:3011–3020

☆ The authors reported no proprietary or commercial interest in any product mentioned in this article.

PII: S1367-0484(10)00055-X

doi: 10.1016/j.clae.2010.04.005

Contact Lens & Anterior Eye
Volume 33, Issue 4 , Pages 167-170 , August 2010

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