Onset time course of solution induced corneal staining

Bandamwar, Kalika L.; Garrett, Qian; Cheung, David; Huang, Jessie; Lee, Ling; Ng, Carina; Papas, Eric B.

doi:10.1016/j.clae.2010.02.004

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Volume 33, Issue 4 , Pages 199-201, August 2010

Onset time course of solution induced corneal staining

Kalika L. Bandamwar
- The Institute for Eye Research, Sydney, NSW, Australia
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
- Corresponding author at: Institute for Eye Research, Level 3, North Wing, RMB, Gate 14, Barker Street, The University of New South Wales, Sydney, NSW 2052, Australia. Tel.: +61 2 9385 7489; fax: +61 2 9385 7401.
Qian Garrett
- The Institute for Eye Research, Sydney, NSW, Australia
- The Vision Cooperative Research Centre, Sydney, NSW, Australia
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
David Cheung
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
Jessie Huang
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
Ling Lee
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
Carina Ng
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
Eric B. Papas
- The Institute for Eye Research, Sydney, NSW, Australia
- The Vision Cooperative Research Centre, Sydney, NSW, Australia
- School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia

published online 16 March 2010.

Abstract

Purpose

To evaluate the early phase time course of solution induced corneal staining.

Methods and materials

A double masked, single centred, prospective clinical trial was conducted. Twenty-five participants, either experienced or new contact lens wearers, participated in the study. Corneal staining response to short term use of ReNu MultiPlus^® Multipurpose Solution and PureVision™ silicon hydrogel contact lens with fluorescein was observed using standard techniques after 15, 30, 45, 60 and 120min of lens wear and graded according to the IER scale. Measurements were carried out on separate days for each time point, in random order.

Results

Mean extent of staining was greater in test than in control eyes at all time points except baseline. In test eyes, the degree of staining increased successively at each time point after insertion, up to, but not beyond, 60min. For those participants presenting with staining, maximum severity and frequency were both observed at 60min and were significantly greater (p<0.05) than at 15, 30, and 45min.

Conclusion

Solution induced corneal staining gradually increased after lens insertion to a maximum at 1h. This level was maintained until at least 2h post-insertion.

Keywords: Solution induced corneal staining (SICS), Silicone hydrogel, Multipurpose solution (MPS), Polyhexamethylene biguanide (PHMB)