Clinical performance of different care systems with silicone hydrogel contact lenses☆

Abstract 

Purpose

To assess the clinical and subjective performance of a one-step hydrogen peroxide (H₂O₂) lens care system compared to a multi-purpose disinfecting system (MPDS) when used with silicone hydrogel (SiH) lenses.

Methods

This was an eight-week, contralateral (lens type) clinical trial with a randomized, cross-over (care system) design. The H₂O₂ system was Clear Care ((AO Sept Plus) CIBA VISION) and the MPDS was OPTI-FREE RepleniSH (Alcon) and the SiH materials were lotrafilcon B (Air Optix; CIBA VISION) and senofilcon A (Acuvue OASYS, Johnson & Johnson Vision Care). Investigators and subjects were masked to lens care and lens type, respectively. Clinical variables and ocular health assessments were conducted at a baseline, two-week and four-week visit for each cross-over phase. Comfort, dryness and vision were rated on 0–100 scales. Wearing times and comfortable wearing times were also recorded.

Results

Twenty-six subjects were enrolled: nine male, 17 female, mean age (±standard deviation) 31±12 years (range 17–59 years) and 24 subjects completed the study. Clinical variables showed no difference between solutions (all p>0.05), however one subject exhibited solution-induced corneal staining with both lens materials and the MPDS. There was no difference between solutions in subjective overall ratings of comfort, dryness or vision (p>0.05). The H₂O₂ resulted in longer reported comfortable wearing times than the MPDS (10.93±1.71 vs 9.84±1.47h; repeated measures ANOVA, p<0.01).

Conclusions

While both lens care systems performed well with the SiH lenses used, the H₂O₂ resulted in a longer reported comfortable wearing time then the MPDS.

Keywords: Contact lens, Care system, Silicone hydrogel, Comfort, Hydrogen peroxide, Multi-purpose