Contact Lens & Anterior Eye
Volume 31, Issue 1 , Pages 29-37, February 2008

Morphologic changes in cat epithelium following continuous wear of orthokeratology lenses: A pilot study☆

  • Jennifer D. Choo

      Affiliations

    • Vision Cooperative Research Centre, Sydney, NSW, Australia
    • Pacific University College of Optometry, Forest Grove, OR, USA
    • Institute for Eye Research, Sydney, NSW, Australia
    • University of New South Wales School of Optometry, Sydney, NSW, Australia
    • Corresponding Author InformationCorresponding author at: Institute for Eye Research, Vision Cooperative Research Centre, Level 3 RMB, Gate 14 Barker Street, Sydney, NSW 2052, Australia. Tel.: +61 2 9385 7611; fax: +61 2 9385 7401.
    • ,
  • Patrick J. Caroline

      Affiliations

    • Pacific University College of Optometry, Forest Grove, OR, USA
    • ,
  • Dustin D. Harlin

      Affiliations

    • Pacific University College of Optometry, Forest Grove, OR, USA
    • ,
  • Eric B. Papas

      Affiliations

    • Vision Cooperative Research Centre, Sydney, NSW, Australia
    • Institute for Eye Research, Sydney, NSW, Australia
    • University of New South Wales School of Optometry, Sydney, NSW, Australia
    • ,
  • Brien A. Holden

      Affiliations

    • Vision Cooperative Research Centre, Sydney, NSW, Australia
    • Institute for Eye Research, Sydney, NSW, Australia
    • University of New South Wales School of Optometry, Sydney, NSW, Australia

published online 04 October 2007.

Abstract 

Purpose

To investigate the sequence of morphologic changes over time in cat epithelium during continuous wear of orthokeratology lenses.

Methods

Four 2-year-old female cats were used; one served as a no lens wear control and three wore custom designed Paragon CRT lenses for myopic and hyperopic correction in the right and left eyes, respectively. Lenses were worn continuously and animals were euthanased after 4h, 8h and 14 days. Corneal tissue was fixed then stained with hematoxylin and eosin for histologic evaluation and measurement of epithelial thickness.

Results

Average epithelial thickness of control eyes in the centre (38±1μm) and mid-periphery (3.0mm from the centre, 38±2μm) of the cornea was similar. Epithelial thickness in myopic corrected eyes showed progressive thinning in the centre and progressive thickening in the mid-periphery with increased lens wearing time. Hyperopic corrected eyes showed the opposite pattern of progressive epithelial thickening in the centre and thinning in the mid-periphery with lens wearing time.

Conclusions

The epithelium appears to play a major role in the changes induced by orthokeratology lenses. The epithelial effects were dependent on time and lens design. Further studies are needed to determine the mechanisms responsible for these changes.

Keywords: Orthokeratology, Histology, Epithelium, Epithelial thickness, Corneal reshaping

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☆ Presented as a paper at The Second Global Orthokeratology Symposium, Toronto, Canada, July 2004, The Fourth Symposium of the Orthokeratology Society of Australia, Gold Coast, Australia, October 2004, and The Society for Orthokeratology in Singapore Meeting, Singapore, April 2005.

PII: S1367-0484(07)00077-X

doi:10.1016/j.clae.2007.07.002

Contact Lens & Anterior Eye
Volume 31, Issue 1 , Pages 29-37, February 2008

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