Contact Lens & Anterior Eye
Volume 30, Issue 2 , Pages 94-107, May 2007

Current concepts: Contact lens related Pseudomonas keratitis☆

  • Danielle M. Robertson

      Affiliations

    • Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
    • ,
  • W. Matthew Petroll

      Affiliations

    • Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
    • ,
  • James V. Jester

      Affiliations

    • The Eye Institute, Department of Ophthalmology, The University of California at Irvine, Irvine, CA, USA
    • ,
  • H. Dwight Cavanagh

      Affiliations

    • Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 214 648 8074; fax: +1 214 648 9061.

published online 07 November 2006.

Abstract 

Despite the development of silicone hydrogel lenses, Pseudomonas aeruginosa (PA) continues to be the leading cause of contact lens related microbial keratitis. Understanding the pathogenesis of PA-mediated corneal infection is critical to the development of new prevention and treatment strategies. Recently intracellular invasion of surface corneal epithelial cells by PA has been revisited as an important element in the infection process. This review identifies the mechanisms involved, and examines the roles of the lens, hypoxia alone, PA stain, cystic fibrosis transmembrane receptor protein (CFTR), and membrane lipid rafts in mediating intracellular invasion in both in vitro and in vivo conditions. Non-toxic blockade of raft formation in vitro or in vivo effectively abrogates PA internalization and may represent a unique, new strategy to prevent or ameliorate lens-related PA microbial keratitis.

Keywords: Cornea, Contact lens, Pseudomonas aeruginosa, Lipid rafts, Cystic fibrosis transmembrane, Receptor protein

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☆ Presented in part as a keynote address at the British Contact Lens Association Annual Meeting, 21 May 2006, Birmingham, England (UK) (HDC).

PII: S1367-0484(06)00134-2

doi:10.1016/j.clae.2006.10.001

Contact Lens & Anterior Eye
Volume 30, Issue 2 , Pages 94-107, May 2007

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