Contact Lens & Anterior Eye
Volume 29, Issue 3 , Pages 135-141 , July 2006

A longitudinal case series investigating cellular changes to the transplanted cornea using confocal microscopy

  • Joanna G. Hollingsworth

      Affiliations

    • Eurolens Research, Moffat Building, The University of Manchester, PO Box 88, Manchester M60 1QD, UK
    • ,
  • Nathan Efron

      Affiliations

    • Institute of Health and Biomedical Innovation, and School of Optometry, Queensland University of Technology, Kelvin Grove 4059, Qld, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 7 3864 5713; fax: +61 7 3864 5665.
    • ,
  • Andrew B. Tullo

      Affiliations

    • Royal Eye Hospital, Oxford Road, Manchester M13 9WH, UK

References 

  1. Bourne WM. Cellular changes in transplanted human corneas. Cornea. 2001;20:560–569
  2. Luo L, Liu Z, Chen L, et al. Confocal microscopy in transplanted human corneas. Yan Ke Xue Bao. 2003;19:201–205
  3. Ricter A, Slowik C, Somodi S, et al. Corneal reinnervation following penetrating keratoplasty—correlation of esthesiometry and confocal microscopy. German J Ophthalmol. 1997;5:513–517
  4. Hollingsworth JG, Bonshek RE, Efron N. Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy. Cornea. 2005;24:397–405
  5. Hollingsworth JG, Perez-Gomez I, Mutalib HA, et al. A population study of the normal cornea using an in vivo slit scanning confocal microscope. Optom Vis Sci. 2001;78:706–711
  6. Efron N, Perez-Gomex I, Mutalib HA, et al. Confocal microscopy of the normal human cornea. Contact Lens Ant Eye. 2001;24:16–23
  7. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374–384
  8. Salla S, Redbrake C, Becker J, Reim M. Remarks on the vitality of the human cornea after organ culture. Cornea. 1995;14:502s–508s
  9. Borderie VM, Baudrimont M, Lopez M, et al. Evaluation of the deswelling period in dextran-containing medium after corneal organ culture. Cornea. 1997;16:215–223
  10. Tsubota K, Yamada M, Naoi S. Specular microscopic observation of human corneal epithelial abnormalities. Ophthalmology. 1991;98:184–191
  11. Bishop PN, Bonshek RE, Jones CJ, et al. Lectin binding sites in normal, scarred, and lattice dystrophy corneas. Br J Ophthalmol. 1991;75:22–27
  12. Meisler DM, Fine M. Recurrence of the clinical signs of lattice corneal dystrophy (type I) in corneal transplants. Am J Ophthalmol. 1984;97:210–214
  13. Imre L, Resch M, Nagymihaly A. In vivo confocal corneal microscopy after keratoplasty. Ophthalmologe. 2005;102:140–146
  14. Muller LJ, Pels E, Vrensen GFJM. The effects of organ-culture on the density of keratocytes and collagen fibers in human corneas. Cornea. 2001;20:86–95
  15. Ohno K, Mitooka K, Nelson LR, et al. Keratocyte activation and apoptosis in transplanted human corneas in a xenograft model. Invest Ophthalmol Vis Sci. 2002;43:1025–1031
  16. Redmond RM, Armitage WJ, Whittle J, et al. Long-term survival of endothelium following transplantation of corneas stored by organ culture. Br J Ophthalmol. 1992;76:479–481
  17. Moller-Pedersen T. Keratocyte reflectivity and corneal haze. Exp Eye Res. 2004;78:553–560
  18. Tervo T, Vannas A, Tervo K, et al. Histochemical evidence of limited reinnervation of human corneal grafts. Acta Ophthalmol. 1985;63:207–214
  19. Harper CL, Boulton ME, Marcyniuk B, et al. Endothelial viability of organ-cultured corneas following penetrating keratoplasty. Eye. 1998;12:834–838
  20. Ing JJ, Ing HH, Nelson LR, et al. Ten-year postoperative results of penetrating keratoplasty. Ophthalmology. 1998;105:1855–1865

PII: S1367-0484(06)00051-8

doi: 10.1016/j.clae.2006.03.005

Contact Lens & Anterior Eye
Volume 29, Issue 3 , Pages 135-141 , July 2006

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