Contact Lens & Anterior Eye
Volume 29, Issue 2 , Pages 93-100 , May 2006

Screening for drug-induced spoliation of the hydrogel optic of the AlphaCor™ artificial cornea

  • David A. Morrison

      Affiliations

    • Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
    • ,
  • Zoya Gridneva

      Affiliations

    • Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
    • ,
  • Traian V. Chirila

      Affiliations

    • Queensland Eye Institute, Brisbane, Qld, Australia
    • School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Qld, Australia
    • ,
  • Celia R. Hicks

      Affiliations

    • Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 8 9381 0877; fax: +61 8 9381 0759.

References 

  1. Chirila TV, Morrison DA, Hicks CR, Gridneva Z, Barry CJ, Vijayasekaran S. In vitro drug-induced spoliation of a keratoprosthetic hydrogel. Cornea. 2004;23:620–629
  2. Hicks CR, Crawford GJ, Lou X, Tan DT, Snibson GR, Sutton G, et al. Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications. Eye. 2003;17:385–392
  3. Hicks CR, Chirila TV, Werner L, Crawford GJ, Apple DJ, Constable IJ. Deposits in artificial corneas: risk factors and prevention. Clin Exp Ophthalmol. 2004;32:185–191
  4. Chirila TV, Gridneva Z, Morrison DA, Barry CJ, Hicks CR, Hill DJT, et al. Spontaneous calcification of acrylic hydrogels in abiotic calcifying media and the relevance of ionic solute effects. J Mater Sci. 2004;39:1861–1864
  5. Chirila TV, Morrison DA, Gridneva Z, Meyrick D, Hicks CR, Webb JM. Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour. Contact Lens Anterior Eye. 2005;28:21–28
  6. Crawford GJ, Hicks CR, Lou X, Vijayasekaran S, Tan D, Mulholland B, et al. The Chirila keratoprosthesis: Phase I human clinical trial. Ophthalmology. 2002;109:883–889
  7. Hicks CR, Crawford GJ, Tan DT, Snibson GR, Sutton GL, Downie N, et al. AlphaCor™ cases. Comparative outcomes. Cornea. 2003;22:583–590
  8. Gaasterland DE, Pederson JE, MacLellan HM, Reddy VN. Rhesus monkey aqueous humor composition and a primate ocular perfusate. Invest Ophthalmol Vis Sci. 1979;18:1139–1150
  9. Caprioli J. The ciliary epithelia and aqueous humor. In:  Hart WM editors. Adler's Physiology of the Eye. 9th ed.. St. Louis: Mosby; 1992;p. 228–247
  10. Ruben M, Tripathi RC, Winder AF. Calcium deposition as a cause of spoilation of hydrophilic soft contact lenses. Br J Ophthalmol. 1975;59:141–148
  11. Abbott JM, Bowers RWJ, Franklin VJ, Tighe BJ. Studies in the ocular compatibility of hydrogels (IV): observations on the role of calcium in deposit formation. J Br Contact Lens Assoc. 1991;14:21–28
  12. Tighe B, Franklin V. Lens deposition and spoilation. In:  Larke JR editors. The Eye in Contact Lens Wear. 2nd ed.. Boston: Butterworth/Heinemann; 1997;p. 49–100
  13. Bucher PJM, Büchi ER, Daicker BC. Dystrophic calcification of an implanted hydroxyethylmethacrylate intraocular lens. Arch Ophthalmol. 1995;113:1431–1435
  14. Fernando GT, Crayford BB. Visually significant calcification of hydrogel intraocular lenses necessitating explantation. Clin Experiment Ophthalmol. 2000;28:280–286
  15. Yu AKF, Kwan KYW, Chan DHY. Clinical features of 46 eyes with calcified hydrogel intraocular lenses. J Cataract Refract Surg. 2001;27:1596–1606
  16. Pandey SK, Werner L, Apple DJ, Gravel JP. Calcium precipitation on the optical surfaces of a foldable intraocular lens: a clinicopathological correlation. Arch Ophthalmol. 2002;120:391–393

PII: S1367-0484(06)00032-4

doi: 10.1016/j.clae.2006.02.007

Contact Lens & Anterior Eye
Volume 29, Issue 2 , Pages 93-100 , May 2006

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