Evaluation of povidone-iodine as a disinfectant solution for contact lenses: Antimicrobial activity and cytotoxicity for corneal epithelial cells

Yanai, Ryoji; Yamada, Naoyuki; Ueda, Kiichi; Tajiri, Motoharu; Matsumoto, Toru; Kido, Keiji; Nakamura, Shigeru; Saito, Fumio; Nishida, Teruo

doi:10.1016/j.clae.2006.02.006

« Previous Next »Contact Lens & Anterior Eye
Volume 29, Issue 2 , Pages 85-91, May 2006

Evaluation of povidone-iodine as a disinfectant solution for contact lenses: Antimicrobial activity and cytotoxicity for corneal epithelial cells

Ryoji Yanai
- Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
- Corresponding author. Tel.: +81 836 22 2277; fax: +81 836 29 2228.
Naoyuki Yamada
- Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
Kiichi Ueda
- Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
Motoharu Tajiri
- Ophtecs Corporation Research Center, Toyooka, Hyogo, Japan
Toru Matsumoto
- Ophtecs Corporation Research Center, Toyooka, Hyogo, Japan
Keiji Kido
- Ophtecs Corporation Research Center, Toyooka, Hyogo, Japan
Shigeru Nakamura
- Ophtecs Corporation Research Center, Toyooka, Hyogo, Japan
Fumio Saito
- Ophtecs Corporation Research Center, Toyooka, Hyogo, Japan
Teruo Nishida
- Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan

published online 17 April 2006.

Abstract

Povidone-iodine (PVP-I) possesses broad-spectrum antimicrobial activity and is used clinically as a disinfectant. We evaluated the disinfectant properties and safety of PVP-I for use as a contact lens solution. The concentrations of PVP-I required to reduce the number of Staphylococcus aureus or Candida albicans by 3 log units were lower than were those of hydrogen peroxide, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BAK). The cytotoxicity of PVP-I for cultured human corneal epithelial (HCE) cells was less than that of the other three agents. The safety margin for PVP-I was thus greatest among the tested compounds. PVP-I appears suited for use as a contact lens disinfectant.

Keywords: Soft contact lens, Disinfection, Povidone-iodine, Hydrogen peroxide, Multipurpose solution, Safety margin