Contact Lens & Anterior Eye
Volume 28, Issue 4 , Pages 185-192 , December 2005

An evaluation of corneal nerve morphology and function in moderate keratoconus

  • Luisa Simo Mannion

      Affiliations

    • Optometry and Neuroscience, Moffat Building, The University of Manchester, PO Box 88, Manchester, M60 1QD, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 161 306 3797; fax: +44 161 306 3887.
  • ,
  • Cindy Tromans

      Affiliations

    • Manchester Royal Eye Hospital, Manchester, UK
  • ,
  • Clare O’Donnell

      Affiliations

    • Optometry and Neuroscience, Moffat Building, The University of Manchester, PO Box 88, Manchester, M60 1QD, UK

References 

  1. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293–322
  2. Brookes NH, Loh I-P, Clover GM, Poole CA, Sherwin T. Involvement of corneal nerves in the progression of keratoconus. Exp Eye Res. 2003;77:515–524
  3. Sherwin T, Brookes NH, Loh IP, Poole CA, Clover GM. Cellular incursion into Bowman's membrane in the peripheral cone of the keratoconic cornea. Exp Eye Res. 2002;74:473–482
  4. Teng CC. Electron microscope study of the pathology of keratoconus: I. Am J Ophthalmol. 1963;18–47
  5. Somodi S, Hahnel C, Slowik C, Richter A, Weiss DG, Guthoff R. Confocal in vivo microscopy and confocal laser-scanning fluorescence microscopy in keratoconus. German J Ophthalmol. 1997;518–525
  6. Hollingsworth JG, Bonshek RE, Efron N. Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy. Cornea. 2005;24:397–405
  7. Hollingsworth JG, Efron N. Observations of banding patterns (Vogt striae) in keratoconus. A confocal microscopy study. Cornea. 2005;24:162–166
  8. Belmonte C, Garcia-Hirschfeld J, Gallar J. Neurobiology of ocular pain. Prog Retin Eye Res. 1997;16:117–156
  9. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res. 2004;78:513–525
  10. Marfurt CF, Kingsley RE, Echtenkamp SE. Sensory and sympathetic innervation of the mammalian cornea. Invest Ophthalmol Vis Sci. 1989;30:461–472
  11. Millodot M, Owens H. Sensitivity and fragility in keratoconus. Acta Ophthalmol. 1983;61:908–917
  12. Hollingsworth J, Efron N. In vivo corneal confocal microscopy in keratoconus. Ophthal Physiol Opt. 2005;25:254–260
  13. Zadnik K, Barr JT, Gordon MO, Edrington TB the CLEK study group. Biomicroscopic signs and disease severity in keratoconus. Cornea. 1996;15:139–146
  14. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297–319
  15. Oliveira-Soto L, Efron N. Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthal Physiol Opt. 2003;23:163–174
  16. Grupcheva CN, Wong T, Riley AF, McGhee CNJ. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2002;30:187–190
  17. Malik RA, Kallinikos P, Abbott CA, van Schie CHM, Morgan P, Efron N, et al. Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia. 2003;46:683–688
  18. Edmund C. Corneal elasticity and ocular rigidity in normal and keratoconic eyes. Acta Ophthalmol. 1988;66:134–140
  19. Chiou AGY, Kaufman SC, Kaz K, Beuerman RW, Kaufman HE. Characterization of epithelial downgrowth by confocal microscopy. J Cat Ref Surg. 1999;25:1172–1174
  20. Müller LJ, Pels L, Vrensen GFJM. Ultrastructural organization of human corneal nerves. Invest Ophthalmol Vis Sci. 1996;37:476–488
  21. Edmund C. Assessment of an elastic model in the pathogenesis of keratoconus. Acta Ophthalmol. 1987;65:545–550
  22. Edmund C. Corneal topography and elasticity in normal and keratoconic eyes. Acta Ophthalmol. 1989;Suppl. 193:1–36
  23. Böhnke M, Masters BR. Confocal microscopy of the cornea. Prog Retin Eye Res. 1999;18(5):553–628
  24. Benítez del Castillo JM, Wasfy MAS, Fernandez C, Garcia-Sanchez J. An in vivo confocal masked study on corneal epithelium and sub-basal nerves in patients with dry eye. Invest Ophthalmol Vis Sci. 2004;45:3030–3035
  25. Grupcheva CN, McGhee CNJ. Assessing the cornea by in vivo confocal microscopy: author reply. Clin Exp Ophthalmol. 2003;31:84–86
  26. Oliveira-Soto L, Efron N. Assessing the cornea by in vivo confocal microscopy. Letters to the Editor. Clin Exp Ophthalmol. 2003;31:83–84
  27. Linna TU, Vesaluoma MH, Pérez-Santonja JJ, Petroll WM, Alió JL, Tervo TMT. Effect of myopic LASIK on corneal sensitivity and morphology of sub-basal nerves. Invest Ophthalmol Vis Sci. 2000;41:393–397
  28. Rosenberg ME, Tervo TMT, Immonen IJ, Müller LJ, Grönhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in Type 1 Diabetes Mellitus. Invest Ophthalmol Vis Sci. 2000;41:2915–2921
  29. Vesaluoma MH, Pérez-Santonja JJ, Petroll WM, Linna TU, Alió JL, Tervo TMT. Corneal stromal changes induced by myopic LASIK. Invest Ophthalmol Vis Sci. 2000;41:369–376
  30. Millodot M. A review of research on the sensitivity of the cornea. Ophthal Physiol Opt. 1984;4:305–318
  31. Murphy PJ, Lawrenson JG, Patel S, Marshall J. Reliability of the Non-Contact Corneal Aesthesiometer and its comparison with the Cochet-Bonnet aesthesiometer. Ophthal Physiol Opt. 1998;18:532–539
  32. Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, et al. Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study. Invest Ophthalmol Vis Sci. 1998;39:2537–2546
  33. Demirbas NH, Pfulgfelder SC. Topographic pattern and apex location of keratoconus on elevation topography maps. Cornea. 1998;17:476–484
  34. Maguire LJ, Bourne WM. Corneal topography of early keratoconus. Am J Ophthalmol. 1989;108:107–112
  35. Tomlinson A, Schwartz CA. Position of the corneal apex in keratoconus. Am J Optom Physiol Opt. 1980;57:29–32
  36. Patel SV, McLaren JW, Hodge DO, Bourne WM. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci. 2002;43:995–1003

PII: S1367-0484(05)00083-4

doi: 10.1016/j.clae.2005.10.005

Contact Lens & Anterior Eye
Volume 28, Issue 4 , Pages 185-192 , December 2005