Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour

Chirila, Traian V.; Morrison, David A.; Gridneva, Zoya; Meyrick, Danielle; Hicks, Celia R.; Webb, John M.

doi:10.1016/j.clae.2004.09.004

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Volume 28, Issue 1 , Pages 21-28, March 2005

Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour

Traian V. Chirila
- Department of Biomaterials and Polymer Research, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun Street, Nedlands 6009, WA, Australia
- Corresponding author. Tel.: +61 8 9381 0856; fax: +61 8 9382 1171.
David A. Morrison
- Department of Biomaterials and Polymer Research, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun Street, Nedlands 6009, WA, Australia
Zoya Gridneva
- Department of Biomaterials and Polymer Research, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun Street, Nedlands 6009, WA, Australia
Danielle Meyrick
- Division of Science and Engineering, Murdoch University, South Street, Murdoch 6150, WA, Australia
Celia R. Hicks
- Department of Biomaterials and Polymer Research, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun Street, Nedlands 6009, WA, Australia
John M. Webb
- Division of Science and Engineering, Murdoch University, South Street, Murdoch 6150, WA, Australia

published online 02 November 2004.

Abstract

Drug-induced spoliation of hydrogels as contact lenses or as implants in the anterior eye is a frequent occurrence in clinical practice. This study explores the capacity of three commercial multipurpose solutions for contact lens care to reduce the spoliation of poly(2-hydroxyethyl methacrylate) (PHEMA) specimens exposed to a simulated aqueous humour formulation and to three topical drugs commonly administered after insertion of artificial corneas (Predsol, Optimol and Depo-Ralovera). ReNu MultiPlus^® (Bausch & Lomb), Complete^® Blink-N-Clean™ Lens Drops (Allergan) and Complete Protein Remover Tablets dissolved in Complete^® ComfortPLUS™ (both from Allergan) were evaluated. All multipurpose solutions were able to dislodge passively the deposits formed on hydrogels in the simulated aqueous and in the presence of Predsol and Optimol, but none were effective against the deposits induced by Depo-Ralovera. A reduction of the calcium content in deposits caused by Predsol and Optimol was confirmed after treatment with the protein remover preparation, while the other multipurpose solutions caused the complete removal of the deposits. In experiments designed to evaluate the preventive action of the multipurpose solutions, no such effects were observed regardless of the drug involved. The prospect of using multipurpose solutions as eye drops following implantation of a hydrogel artificial cornea is a valid alternative for reducing device spoliation, however it appears to depend on the nature of the postoperative medication.

Keywords: Hydrogels, Spoliation, Artificial cornea, Multipurpose solutions, Aqueous humour, Topical medication