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You searched for Dry eye disease in All Content

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The scientific dry eye disease journey: From the beginning to the end of the beginning

Cited in Scopus: 0

David A. Sullivan

DOI: http://dx.doi.org/10.1016/j.clae.2017.11.001

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: November 20, 2017

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xIn Alice’s Adventures in Wonderland the White Rabbit asks “Where shall I begin…?” “Begin at the beginning,” the King said…” and go on till you come to the end…” [1] My beginning to understand dry eye disease (DED) began in 1982 (Fig. 1), when I was recruited into the eye field. My first step was to learn what was known about DED. In the early 1980’s the pathophysiology of dry eye DED, then called keratoconjunctivitis sicca (KCS), was attributed primarily to aqueous tear deficiency [2,3]. Indeed, it was thought that Sjögren syndrome represented “the greatest single cause of KCS worldwide, excluding those countries wherein trachoma remains epidemic [4].” Additional etiologies for KCS were believed to be estrogen deficiency at/after menopause, lacrimal duct obstruction, mucin insufficiency (e.g.

Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

Cited in Scopus: 0

Chih-Huang Yang, Julie Albietz, Damien G. Harkin, Michael G. Kimlin, Katrina L. Schmid

DOI: http://dx.doi.org/10.1016/j.clae.2017.09.007

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: September 11, 2017

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xTo determine the possible association between serum vitamin D levels and dry eye symptoms, and the impact of an oral vitamin D supplement.

Tear physiology in dry eye associated with chronic graft vs host disease

Cited in Scopus: 0

Alan Tomlinson, Santosh Khanal

DOI: http://dx.doi.org/10.1016/S1367-0484(11)60072-6

Contact Lens and Anterior Eye, Vol. 34, S14

Published in issue: December 01, 2011

Dry eye disease in an adult population in South-West Nigeria

Cited in Scopus: 2

Segun I. Olaniyan, Oluyemi Fasina, Charles O. Bekibele, Ayobade O. Ogundipe

DOI: http://dx.doi.org/10.1016/j.clae.2016.06.008

Contact Lens and Anterior Eye, Vol. 39, Issue 5, p359–364

Published online: July 7, 2016

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xDry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is usually accompanied by increased osmolarity of the tear film and inflammation of the ocular surface [1]. Several population-based studies [2–5] have reported the prevalence of DED ranging from 5% [5] to 35% [4]. This wide disparity in prevalence has been attributed to racial differences in the epidemiology of DED and lack of standardized diagnostic definition [1].

Agreement in dry eye management between optometrists and general practitioners in primary health care in the Netherlands

Cited in Scopus: 2

M.M.A. van Tilborg, Paul J. Murphy, K.S.E. Evans

DOI: http://dx.doi.org/10.1016/j.clae.2015.03.005

Contact Lens and Anterior Eye, Vol. 38, Issue 4, p283–293

Published online: April 18, 2015

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xDry eye disease (DED) is a multi-factorial chronic ocular disease, with significant impact on visual functioning and daily life. This highly symptomatic, chronic condition is experienced by patients in a variety of symptoms that range from ocular discomfort to pain, from an impaired visual performance to photophobia, and so careful questioning is important for good diagnosis [1−4]. The multi-factorial nature of DED makes it difficult to define in one symptom or by any single current investigative technique, and, most importantly, no single treatment works for all.

Epidemiology of symptoms of dry eye disease (DED) in Jordan: A cross-sectional non-clinical population-based study

Cited in Scopus: 4

May M. Bakkar, Wisam A. Shihadeh, Mera F. Haddad, Yousef S. Khader

DOI: http://dx.doi.org/10.1016/j.clae.2016.01.003

Contact Lens and Anterior Eye, Vol. 39, Issue 3, p197–202

Published online: January 29, 2016

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xDry eye disease (DED) is a common ocular disorder that is defined by the 2007 International Dry Eye Workshop (DEWS) as a multifactorial disease of the tears and ocular surface that is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface [1].

Application of a new grading scale for tear ferning in non-dry eye and dry eye subjects

Cited in Scopus: 4

Ali M. Masmali, Sultan AL-Qhtani, Talha M. Al-Gasham, Gamal A. El-Hiti, Christine Purslow, Paul J. Murphy

DOI: http://dx.doi.org/10.1016/j.clae.2014.09.007

Contact Lens and Anterior Eye, Vol. 38, Issue 1, p39–43

Published online: October 8, 2014

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xThe tear film has three main functions: maintenance of ocular surface health, creation of a smooth optical surface for clear vision, and protection of the eye from foreign bodies and infection. It consists of three main layers [1–4]. The outermost layer of the tear film is the lipid layer. This layer acts to limit evaporation of the aqueous component, as well as providing lubrication for eyelid movement and a smooth optical surface [5]. The middle layer consists principally of water, which contains ions and nutrients to supply the corneal and conjunctival epithlelia, as well as immunological proteins for ocular defence against infections [6].

Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms?

Cited in Scopus: 0

Laika Essa, Deborah Laughton, James S. Wolffsohn

DOI: http://dx.doi.org/10.1016/j.clae.2017.07.007

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: August 12, 2017

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xDry eye signs and symptoms are typically triggered by a dysfunction of the ocular tear film, which may arise due to deficiencies in the aqueous phase of the tear film (termed aqueous-deficient dry eye) and, more commonly, the lipid phase of the tear film (termed evaporative dry eye) [1]. The primary course of dry eye treatment is topical application of eye drops, gels and sprays to re-build and stabilise the tear film. Numerous compositions of dry eye treatments are commercially available, principally differing in which element of the tear film they primarily aim to replace.

The potential influence of Schirmer strip variables on dry eye disease characterisation, and on tear collection and analysis

Cited in Scopus: 0

Nery García-Porta, Aisling Mann, Virginia Sáez-Martínez, Val Franklin, James S. Wolffsohn, Brian Tighe

DOI: http://dx.doi.org/10.1016/j.clae.2017.09.012

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: September 23, 2017

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xIt is estimated that between 5 and 30% of the population suffer from dry eye disease (DED) and symptoms of dryness are very commonly reported by patients in eye care clinics [1–3]. Aqueous tear deficiency, which is related to a reduction of the lacrimal tear secretion and dysfunction, is one of the two main categories of DED and Schirmer strips (SS) are still widely used today to measure tear production for DED diagnosis [4–7]. The test was first described in 1903 by Otto Schirmer [8]. It uses absorbent filter paper strips, which are inserted into the temporal lower conjunctival sac and after 5 min the length of wetting of the strip is recorded in millimetres.

Comparison of treatment effect across varying severities of meibomian gland dropout

Cited in Scopus: 0

Philip R.K. Turnbull, Stuti L. Misra, Jennifer P. Craig

DOI: http://dx.doi.org/10.1016/j.clae.2017.09.004

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: September 30, 2017

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xMeibomian gland dysfunction (MGD) is a leading cause of dry eye, affecting around 33% of people younger than 30 years old, and increasing significantly with age [1]. The early stages of MGD show hyper-keratinisation of the MG duct, and meibum with reduced outflow [2], modified composition [3], and increased melting point. As the disease progresses, meibum outflow further decreases, leading to complete stasis of oils from the gland, and to MG atrophy, observed clinically as loss of the gland (MG dropout).

Use of mini scleral contact lenses in moderate to severe dry eye

Cited in Scopus: 21

Fateme Alipour, Ahmad Kheirkhah, Mahmoud Jabarvand Behrouz

DOI: http://dx.doi.org/10.1016/j.clae.2012.07.006

Contact Lens and Anterior Eye, Vol. 35, Issue 6, p272–276

Published online: August 20, 2012

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xTo evaluate fitting feasibility and efficacy of mini scleral contact lenses in moderate to severe dry eye patients.

Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment

Cited in Scopus: 0

Duygu Acar, Irene Teresa Molina-Martínez, Miguel Gómez-Ballesteros, Manuel Guzmán-Navarro, José Manuel Benítez-del-Castillo, Rocío Herrero-Vanrell

DOI: http://dx.doi.org/10.1016/j.clae.2017.11.004

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: December 6, 2017

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xDry eye disease (DED) is a highly prevalent health problem affecting approximately 5–35% of the world’s population [1]. It is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability [2]. DED is associated with a significant adverse impact on vision-related quality of life, causing difficulties in daily activities [3,4]. It can be caused by various factors such as meibomian gland dysfunction, low blink rate, ocular surface disorders and contact lens wear, among others, resulting in the alteration of the tear film [2].

Survey of eye practitioners’ preference of diagnostic tests and treatment modalities for dry eye in Ghana

Cited in Scopus: 1

Kofi Asiedu, Samuel Kyei, Benedict Ayobi, Frank Okyere Agyemang, Reynolds Kwame Ablordeppey

DOI: http://dx.doi.org/10.1016/j.clae.2016.08.001

Contact Lens and Anterior Eye, Vol. 39, Issue 6, p411–415

Published online: August 6, 2016

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xThis study sought to provide an evidence-based profile of the diagnosis, treatment and knowledge or opinions on dry eye among optometrists and ophthalmologists in Ghana.

Dry eye and Meibomian gland dysfunction with meibography in patients with lamellar ichthyosis

Cited in Scopus: 0

Melis Palamar, Irmak Karaca, Huseyin Onay, Ilgen Ertam, Ayse Yagci

DOI: http://dx.doi.org/10.1016/j.clae.2017.06.001

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: June 20, 2017

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xTo evaluate the dry eye findings and Meibomian gland dysfunction as demonstrated with meibography in patients with lamellar ichthyosis.

Conjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lenses

Cited in Scopus: 0

Sarah La Porta Weber, Rossen Mihaylov Hazarbassanov, Alex Nasaré, José Álvaro Pereira Gomes, Ana Luisa Hofling-Lima

DOI: http://dx.doi.org/10.1016/j.clae.2016.12.008

Contact Lens and Anterior Eye, Vol. 40, Issue 3, p151–156

Published online: January 6, 2017

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xDry eye disease (DED) is a common tear film disorder that is caused by a tear deficiency or excessive tear evaporation, which can lead to severe disease in the cornea and conjunctiva. Affected individuals may experience many symptoms, such as foreign-body sensation, ocular fatigue and eye redness [1,2].

Estimating basal tear osmolarity in normal and dry eye subjects

Cited in Scopus: 0

Catherine Willshire, Roger J. Buckley, Anthony J. Bron

DOI: http://dx.doi.org/10.1016/j.clae.2017.09.005

Publication stage: In Press Corrected Proof

Contact Lens and Anterior Eye

Published online: September 22, 2017

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xTear osmolarity (tOsm) is used as a measure of severity in dry eye disease (DED) and has been proposed as an index of body hydration. In DED the level of tear hyperosmolarity is compared with that of a control population. It is proposed here that a better index of body hydration and a more valid reference point in DED can be acquired by measuring the tOsm after a period of evaporative suppression.

Rose bengal staining as an assessment of ocular surface damage and recovery in dry eye disease—A review

Cited in Scopus: 12

Michael J. Doughty

DOI: http://dx.doi.org/10.1016/j.clae.2013.07.008

Contact Lens and Anterior Eye, Vol. 36, Issue 6, p272–280

Published online: August 7, 2013

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xTo review the use of ophthalmic rose bengal to assess the ocular surface, especially considering the grading scales used.

Screening for dry eye disease using infrared ocular thermography

Cited in Scopus: 1

Li Li Tan, Srinivasan Sanjay, Philip B. Morgan

DOI: http://dx.doi.org/10.1016/j.clae.2016.08.004

Contact Lens and Anterior Eye, Vol. 39, Issue 6, p442–449

Published online: August 24, 2016

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xDry eye disease (DED) is a commonly encountered condition in clinical practice and affects up to 12.3% of the population in Singapore [1] with a world prevalence range of 5–38% [2]. The condition has remarkably impact on daily social and physical functioning, work place productivity and quality-of-life [3–6]. Diagnosing the disease can be a tedious and challenging task [7] and been hampered by the lack of objective tests with sufficient sensitivity and specificity, adequate repeatability, ease of performance, and suitability for the clinical practice setting particularly in early or mild cases [8].

Temperature profiles of patient-applied eyelid warming therapies

Cited in Scopus: 2

Michael T.M. Wang, Akilesh Gokul, Jennifer P. Craig

DOI: http://dx.doi.org/10.1016/j.clae.2015.06.002

Contact Lens and Anterior Eye, Vol. 38, Issue 6, p430–434

Published online: June 27, 2015

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xTo compare temperature profile characteristics (on and off eye) of two patient-applied heat therapies for meibomian gland dysfunction (MGD): an eye mask containing disposable warming units (EyeGiene^®) and a microwave-heated flaxseed eye bag^® (MGDRx EyeBag^®).

Dry eye disease: Prevalence, distribution and determinants in a hospital-based population

Cited in Scopus: 14

Stella N. Onwubiko, Boniface I. Eze, Nnemma N. Udeh, Obinna C. Arinze, Ernest N. Onwasigwe, Rich E. Umeh

DOI: http://dx.doi.org/10.1016/j.clae.2013.09.009

Contact Lens and Anterior Eye, Vol. 37, Issue 3, p157–161

Published online: October 14, 2013

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xTo determine the prevalence, distribution and risk factors for dry eye disease (DED) in a tertiary ophthalmic outpatient population.

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